Reactome | RPN1 [endoplasmic reticulum membrane]

RPN1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-264994

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike protein gets N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        RPN1 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04843 RPN1

Gene Names

RPN1

Chain

signal peptide:1-23, chain:24-607

Reference Genes

BioGPS Gene:6184 RPN1

COSMIC (genes):RPN1 RPN1

CTD Gene:6184 RPN1

dbSNP Gene:6184 RPN1

ENSEMBL:ENSG00000163902 RPN1

ENSEMBL_homo_sapiens_GENE:ENSG00000163902.12 RPN1

HGNC:10381 RPN1

KEGG Gene (Homo sapiens):6184 RPN1

Monarch:6184 RPN1

NCBI Gene:6184 RPN1

OMIM:180470 RPN1

UCSC:P04843 RPN1

Reference Transcript

RefSeq:NM_002950.3 RPN1

Other Identifiers

11742852_a_at

11742853_x_at

11748113_a_at

11749429_a_at

16958864

201011_PM_at

201011_at

2694398

2694399

2694400

2694401

2694403

2694404

2694405

2694407

2694409

2694411

2694412

2694415

2694418

2694419

2694420

33424_at

6184

8090490

A_23_P132809

A_23_P254340

A_24_P63262

GE58292

GO:0003723

GO:0003824

GO:0004579

GO:0005515

GO:0005783

GO:0005789

GO:0005791

GO:0005829

GO:0006486

GO:0006487

GO:0008250

GO:0016020

GO:0016740

GO:0018279

GO:0031410

GO:0036211

GO:0042470

GO:0043226

GO:1901135

HMNXSV003047593

ILMN_1660533

TC03001757.hg

Y00281_at

g4506674_3p_at

Participates

as a component of

Cross References

RefSeq

NP_002941.1

OpenTargets

ENSG00000163902

HPA

ENSG00000163902-RPN1

GeneCards

P04843

Ensembl

ENSG00000163902, ENSP00000296255, ENST00000296255

PRO

P04843

Pharos - Targets

P04843

Orphanet

22987

HMDB Protein

HMDBP01589

PDB

8B6L, 6S7O, 6S7T

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	22
UniProt:Q14165 MLEC	3	MLEC [plasma membrane] (R-HSA-6806292) MLEC [specific granule membrane] (R-HSA-6799618) MLEC [endoplasmic reticulum membrane] (R-HSA-901082)	0.589	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.499	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.483	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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