Reactome | RPN2 [endoplasmic reticulum membrane]

RPN2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-264937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike protein gets N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        RPN2 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04844 RPN2

Gene Names

RPN2

Chain

signal peptide:1-22, chain:23-631

Reference Genes

BioGPS Gene:6185 RPN2

COSMIC (genes):RPN2 RPN2

CTD Gene:6185 RPN2

dbSNP Gene:6185 RPN2

ENSEMBL:ENSG00000118705 RPN2

ENSEMBL_homo_sapiens_GENE:ENSG00000118705.18 RPN2

ENSEMBL_homo_sapiens_GENE:ENSG00000291973.1 RPN2

HGNC:10382 RPN2

KEGG Gene (Homo sapiens):6185 RPN2

Monarch:6185 RPN2

NCBI Gene:6185 RPN2

OMIM:180490 RPN2

UCSC:P04844 RPN2

Reference Transcript

Other Identifiers

11715660_a_at

16913378

208689_PM_s_at

208689_s_at

213399_PM_x_at

213399_x_at

213491_PM_x_at

213491_x_at

36676_at

3884102

3884103

3884105

3884108

3884110

3884117

3884118

3884119

3884120

3884121

3884123

3884124

3884129

3884130

3884134

3884136

3884137

3884138

3884143

3884146

3884147

3884148

3884149

6185

8062349

A_23_P108994

A_33_P3240258

A_33_P3332145

GE81214

GO:0003824

GO:0004579

GO:0005515

GO:0005634

GO:0005654

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0008250

GO:0016020

GO:0016604

GO:0016740

GO:0018279

GO:0036211

GO:0043226

GO:1901135

HMNXSV003027642

ILMN_1693421

TC20000271.hg

Y00282_at

g13097707_3p_a_at

Participates

as a component of

Cross References

RefSeq

NP_001311230.1, NP_001311228.1, NP_001311234.1, NP_001311231.1, NP_001311235.1, NP_001311232.1, NP_001129243.1, NP_001311233.1, NP_002942.2

OpenTargets

ENSG00000118705

GeneCards

P04844

HPA

ENSG00000118705-RPN2

Ensembl

ENST00000373622, ENSP00000237530, ENSG00000118705, ENST00000237530, ENSP00000362724

PRO

P04844

Pharos - Targets

P04844

HMDB Protein

HMDBP01592

PDB

6S7T, 6S7O, 8B6L

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	3
UniProt:Q14165 MLEC	3	MLEC [plasma membrane] (R-HSA-6806292) MLEC [specific granule membrane] (R-HSA-6799618) MLEC [endoplasmic reticulum membrane] (R-HSA-901082)	0.564	2
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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