Reactome | apoA-I binds to CUBN:AMN

apoA-I binds to CUBN:AMN

Stable Identifier

R-HSA-264848

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Extracellular apoA-I protein binds to the CUBN (cubilin) subunit of the CUBN:AMN complex associated with the plasma membrane. In the body, this complex is found on the apical surfaces of kidney glomerular cells, where it mediates binding and endocytosis of proteins in the glomerular filtrate, and on the apical surfaces of enterocytes, where it mediates uptake of several vitamins complexed with carrier proteins (notably vitamin B12 (cobalamin):intrinsic factor) (Kozyraki et al. 1999; Fyfe et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
10371504	The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein Fyfe, JC, Krahe, R, Kozyraki, R, Kristiansen, M, Moestrup, SK, Aminoff, M, de la Chapelle, A, Jacobsen, C, Verroust, PJ, Cui, S, Christensen, EI, Gerdes, C	Nat Med	1999
17652309	Apolipoprotein A-II is catabolized in the kidney as a function of its plasma concentration Chambaz, J, Pastier, D, Cywiner-Golenzer, C, Dugué-Pujol, S, Chabert, M, Rousset, X, Châtelet, FP, Demeurie, J, Verroust, PJ, Kalopissis, AD, Château, D, Klein, C	J Lipid Res	2007