activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

Stable Identifier
R-HSA-2562542
Type
Complex
Species
Homo sapiens
Compartment
endosome membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
16115877 Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

Fitzgerald, KA, Cusson-Hermance, N, Khurana, S, Kelliher, MA, Lee, TH

J Biol Chem 2005
15814722 Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

Offermann, MK, Kaiser, WJ

J Immunol 2005
21737330 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Langlais, C, Geserick, P, Kellert, B, Häcker, G, Cain, K, Feoktistova, M, Hupe, M, MacFarlane, M, Leverkus, M, Dimitrova, DP

Mol. Cell 2011
Participants
components
Participates
as an output of
as an input of
Inferred To
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
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