activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

Stable Identifier
R-HSA-2562542
Type
Complex
Species
Homo sapiens
Compartment
endosome membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
15814722 Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

Kaiser, WJ, Offermann, MK

J Immunol 2005
16115877 Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

Cusson-Hermance, N, Khurana, S, Lee, TH, Fitzgerald, KA, Kelliher, MA

J Biol Chem 2005
21737330 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Feoktistova, M, Geserick, P, Kellert, B, Dimitrova, DP, Langlais, C, Hupe, M, Cain, K, MacFarlane, M, Häcker, G, Leverkus, M

Mol. Cell 2011
Participants
components
Participant Of
output
input
Inferred To
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Danio rerio)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)