TLR4-induced ripoptosome assembly

Stable Identifier
R-HSA-2562541
Type
Reaction [binding]
Species
Homo sapiens
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TRIF was repored to efficiently induce apoptosis when overexpressed in human HEK293T cells. TRIF-induced apoptosis occurred through activation of the FADD-caspase-8 axis (Kaiser WJ and Offermann MK 2005; Kalai M et al. 2002; Estornes Y et al. 2012). C-terminus of TRIF was shown to form complexes with both RIP1 and RIP3, and disruption of these interactions by mutating the RHIM eliminated the ability of TRIF to induce apoptosis (Kaiser WJ and Offermann MK 2005).

Prevention of RIP1 ubiquitination leads to a strong association of RIP1 and caspase-8 (Feoktistova M et al. 2011, Tenev et al. 2011).

Literature References
PubMed ID Title Journal Year
12752666 Caspase-activation pathways in apoptosis and immunity

Creagh, EM, Conroy, H, Martin, SJ

Immunol Rev 2003
15814722 Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

Kaiser, WJ, Offermann, MK

J Immunol 2005
21737329 The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

Tenev, T, Bianchi, K, Darding, M, Broemer, M, Langlais, C, Wallberg, F, Zachariou, A, Lopez, J, MacFarlane, M, Cain, K, Meier, P

Mol. Cell 2011
14739303 Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways

Han, KJ, Su, X, Xu, LG, Bin, LH, Zhang, J, Shu, HB

J. Biol. Chem. 2004
21737330 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Feoktistova, M, Geserick, P, Kellert, B, Dimitrova, DP, Langlais, C, Hupe, M, Cain, K, MacFarlane, M, H├Ącker, G, Leverkus, M

Mol. Cell 2011
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