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PPM1D [nucleoplasm]
Stable Identifier
R-HSA-2562518
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WIP1, Protein phosphatase 1D
Locations in the PathwayBrowser for interactor UniProt:P16104 H2AFX
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
PPM1D dephosphorylates RUNX2 (Homo sapiens)
PPM1D [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15297 PPM1D
Gene Names
PPM1D, WIP1
Chain
chain:1-605
Reference Genes
BioGPS Gene:8493 PPM1D
COSMIC (genes):PPM1D PPM1D
CTD Gene:8493 PPM1D
dbSNP Gene:8493 PPM1D
ENSEMBL:ENSG00000170836 PPM1D
HGNC:9277 PPM1D
KEGG Gene (Homo sapiens):8493 PPM1D
Monarch:8493 PPM1D
NCBI Gene:8493 PPM1D
OMIM:605100 PPM1D
UCSC:O15297 PPM1D
Reference Transcript
RefSeq:NM_003620.3 PPM1D
Other Identifiers
0006110242
04658+3.1.3.16
04660+3.1.3.16
05235+3.1.3.16
11739369_s_at
11739370_a_at
11751018_a_at
11752090_a_at
16836684
204566_at
22277
230330_at
37107_at
3729538
3729539
3729540
3729541
3729542
3729543
3729546
3729549
3729550
3729551
3729552
3729553
3729554
3729556
3729557
3729558
3729559
3729560
51609_r_at
8008922
8493
A0A0S2Z4M2
A_14_P126509
A_32_P150030
A_33_P3302696
AAB61637
AAH16480
AAH42418
AAH60877
AAP88782
AC011921
AC110602
AC111155
ALQ33878
BC016480
BC042418
BC060877
BT009780
CCDS11625
CH471179
EAW51408
EAW51409
ENSG00000170836
ENSP00000306682
ENSP00000376720
ENSP00000486573
ENST00000305921
ENST00000305921.7
ENST00000392995
ENST00000392995.7
ENST00000629650
ENST00000629650.2
EntrezGene:8493
EntrezGene:PPM1D
g4505996_3p_at
GE79845
GO:0000086
GO:0000278
GO:0003674
GO:0003824
GO:0004674
GO:0004721
GO:0004722
GO:0004724
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006306
GO:0006342
GO:0006367
GO:0006464
GO:0006468
GO:0006470
GO:0006950
GO:0007049
GO:0007165
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0009267
GO:0009314
GO:0009617
GO:0016301
GO:0016787
GO:0016791
GO:0019899
GO:0030330
GO:0034641
GO:0035970
GO:0043167
GO:0043169
GO:0043226
GO:0045814
GO:0046872
GO:0051019
GO:0051276
HGNC:9277
HPA022277
Hs.286073.0.A1_3p_at
ILMN_1670875
IPR000222
IPR001932
IPR015655
IPR036457
K7EJH1
KU178420
LRG_770
LRG_770t1
MIM:114480
MIM:605100
MIM:617450
NM_003620
NP_003611
PF00481
PH_hs_0023484
PPM1D
PPM1D-201
PPM1D-202
PPM1D-204
SM00332
TC17000739.hg
TC17002305.hg
U78305
UPI00000745DC
UPI0000130FE8
XR_934577
Inferred To
PPM1D [nucleoplasm] (Bos taurus)
PPM1D [nucleoplasm] (Caenorhabditis elegans)
PPM1D [nucleoplasm] (Canis familiaris)
PPM1D [nucleoplasm] (Danio rerio)
PPM1D [nucleoplasm] (Drosophila melanogaster)
PPM1D [nucleoplasm] (Gallus gallus)
PPM1D [nucleoplasm] (Mus musculus)
PPM1D [nucleoplasm] (Rattus norvegicus)
PPM1D [nucleoplasm] (Sus scrofa)
PPM1D [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_003611.1
OpenTargets
ENSG00000170836
IntEnz
3.1.3.16
GeneCards
O15297
ZINC - Substances
PPM1D_HUMAN
ZINC target
O15297
PRO
O15297
Orphanet
23354
HMDB Protein
HMDBP08794
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13950 RUNX2
0.602
4
UniProt:Q00987 MDM2
11
SUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.544
4
UniProt:P16104 H2AFX
7
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
H2AFX [nucleoplasm]
(R-HSA-56151)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [extracellular region]
(R-HSA-977583)
0.544
3
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