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MAPKAPK5 [nucleoplasm]
Stable Identifier
R-HSA-2562517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PRAK, MAP kinase-activated protein kinase 5, p38-regulated/activated protein kinase
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)
p38 MAPK:MAPKAPK5 [nucleoplasm] (Homo sapiens)
MAPKAPK5 [nucleoplasm] (Homo sapiens)
phospho-p38 MAPK: MAPKAPK5 [nucleoplasm] (Homo sapiens)
MAPKAPK5 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)
phospho-p38 MAPK: MAPKAPK5 [nucleoplasm] (Homo sapiens)
MAPKAPK5 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MYC positively regulates MAPKAPK5 gene expression (Homo sapiens)
MAPKAPK5 [nucleoplasm] (Homo sapiens)
PKA phosphorylates MAPKAPK5 (Homo sapiens)
MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-S MAPK6,4 binds MAPKAPK5 (Homo sapiens)
MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-S MAPK6,4:MAKPAPK5 [nucleoplasm] (Homo sapiens)
MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-S MAPK6,4 phosphorylate MAPKAPK5 (Homo sapiens)
p-S MAPK6,4:MAKPAPK5 [nucleoplasm] (Homo sapiens)
MAPKAPK5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IW41 MAPKAPK5
Gene Names
MAPKAPK5, PRAK
Chain
chain:1-473
Reference Genes
BioGPS Gene:8550 MAPKAPK5
CTD Gene:8550 MAPKAPK5
dbSNP Gene:8550 MAPKAPK5
ENSEMBL:ENSG00000089022 MAPKAPK5
HGNC:6889 MAPKAPK5
KEGG Gene (Homo sapiens):8550 MAPKAPK5
Monarch:8550 MAPKAPK5
NCBI Gene:8550 MAPKAPK5
OMIM:606723 MAPKAPK5
UCSC:Q8IW41 MAPKAPK5
Reference Transcript
RefSeq:NM_003668.3 MAPKAPK5
RefSeq:NM_139078.2 MAPKAPK5
Other Identifiers
0005720446
11723970_at
15515
16757181
16757209
212871_at
228925_at
3432139
3432140
3432145
3432146
3432147
3432148
3432149
3432150
3432151
3432153
3432156
3432157
3432160
3432161
3432163
3432167
3432168
3432169
3432170
3432171
3432172
3432173
3432174
3432175
3432176
3432179
3432180
3432181
3432182
3432183
3432184
3432185
3432186
3432187
3432188
3432189
3432204
3432206
3432208
3432210
3432212
3432214
41506_at
4546
7958800
8550
86882_at
A_14_P113146
A_14_P200357
A_21_P0000668
A_23_P87810
A_24_P124662
AAC39863
AAH00833
AAH41049
AAH47284
AF032437
AK122767
AL110301
BAG53717
BC000833
BC041049
BC047284
CAB004546
CAB53747
CCDS44975
CCDS44976
CH471054
EAW97981
ENSG00000089022
ENSP00000449381
ENSP00000449667
ENST00000550735
ENST00000550735.6
ENST00000551404
ENST00000551404.6
EntrezGene:8550
EntrezGene:MAPKAPK5
F8VRP2
GE54249
GE716401
GE831332
GE87779
GO:0000165
GO:0000166
GO:0000187
GO:0002039
GO:0003674
GO:0004672
GO:0004674
GO:0004683
GO:0004708
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0007265
GO:0007568
GO:0008150
GO:0009058
GO:0009931
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019899
GO:0032007
GO:0032212
GO:0034641
GO:0035556
GO:0042592
GO:0043167
GO:0043226
GO:0046777
GO:0051019
GO:0051276
GO:0051973
GO:0090400
GO:1901796
GO:1904355
HGNC:6889
HPA015515
Hs.207422.0.A1_3p_at
Hs.30327.0.S1_3p_at
ILMN_1699082
ILMN_2322935
IPR000719
IPR008271
IPR011009
MAPKAPK5
MAPKAPK5-206
MAPKAPK5-207
MIM:606723
NM_003668
NM_139078
NP_003659
NP_620777
PF00069
PH_hs_0024960
R4GN33
R4GN93
SM00220
TC12000872.hg
TC12000873.hg
TC12002570.hg
UPI0000074563
UPI0000161429
XM_017020125
XM_017020126
XM_017020127
XM_017020128
XM_017020129
XM_017020130
XM_017020131
XP_016875614
XP_016875615
XP_016875616
XP_016875617
XP_016875618
XP_016875619
XP_016875620
Participant Of
output
MYC positively regulates MAPKAPK5 gene expression
input
p-S MAPK6,4 binds MAPKAPK5
PKA phosphorylates MAPKAPK5
hasComponent
p-S MAPK6,4:MAKPAPK5 [nucleoplasm]
p38 MAPK:MAPKAPK5 [nucleoplasm]
phospho-p38 MAPK: MAPKAPK5 [nucleoplasm]
Other forms of this molecule
p-T182 MAPKAPK5 [cytosol]
p-S115 MAPKAPK5 [cytosol]
p-S115 MAPKAPK5 [nucleoplasm]
p-T182-MAPKAPK5 [nucleoplasm]
Inferred To
MAPKAPK5 [nucleoplasm] (Bos taurus)
MAPKAPK5 [nucleoplasm] (Canis familiaris)
MAPKAPK5 [nucleoplasm] (Danio rerio)
MAPKAPK5 [nucleoplasm] (Dictyostelium discoideum)
MAPKAPK5 [nucleoplasm] (Gallus gallus)
MAPKAPK5 [nucleoplasm] (Mus musculus)
MAPKAPK5 [nucleoplasm] (Plasmodium falciparum)
MAPKAPK5 [nucleoplasm] (Rattus norvegicus)
MAPKAPK5 [nucleoplasm] (Saccharomyces cerevisiae)
MAPKAPK5 [nucleoplasm] (Sus scrofa)
MAPKAPK5 [nucleoplasm] (Xenopus tropicalis)
Homologues of MAPKAPK5 [nucleoplasm] (Dictyostelium discoideum)
Homologues of MAPKAPK5 [nucleoplasm] (Plasmodium falciparum)
Cross References
ZINC - Investigational
MAPK5_HUMAN
RefSeq
NP_003659.2
,
NP_620777.1
ZINC - World Drugs
MAPK5_HUMAN
OpenTargets
ENSG00000089022
GeneCards
Q8IW41
ZINC - Substances
MAPK5_HUMAN
ZINC - Biogenic
MAPK5_HUMAN
ZINC target
Q8IW41
PRO
Q8IW41
ZINC - Predictions - Purchasable
MAPK5_HUMAN
HMDB Protein
HMDBP01196
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16659 MAPK6
6
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
0.848
7
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.664
6
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