Reactome | ESPL1(1536-2120) [cytosol]

ESPL1(1536-2120) [cytosol]

Stable Identifier

R-HSA-2467767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ESPL1 C-terminus, Separin C-terminus, Separase C-terminus

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q14674 ESPL1

Gene Names

ESPL1, ESP1, KIAA0165

Chain

chain:1-2120

Reference Genes

BioGPS Gene:9700 ESPL1

COSMIC (genes):ESPL1 ESPL1

CTD Gene:9700 ESPL1

dbSNP Gene:9700 ESPL1

ENSEMBL:ENSG00000135476 ESPL1

ENSEMBL_homo_sapiens_GENE:ENSG00000135476.12 ESPL1

HGNC:16856 ESPL1

KEGG Gene (Homo sapiens):9700 ESPL1

Monarch:9700 ESPL1

NCBI Gene:9700 ESPL1

OMIM:604143 ESPL1

UCSC:Q14674 ESPL1

Reference Transcript

Other Identifiers

11723909_at

11748054_a_at

16751709

204817_PM_at

204817_at

3415858

3415860

3415862

3415863

3415864

3415865

3415866

3415867

3415868

3415869

3415870

3415871

3415872

3415873

3415877

3415878

3415880

3415881

3415882

3415883

3415884

3415885

3415886

3415887

3415889

3415890

3415891

3415892

3415894

3415895

3415896

3415897

3415899

3415900

3415902

3415904

3415905

3415906

3415907

3415908

3415909

3415910

3415911

3415912

3415913

3415914

38158_PM_at

38158_at

7955736

9700

A_23_P32707

A_32_P119007

D79987_at

GE79012

GO:0000070

GO:0000212

GO:0000278

GO:0000280

GO:0000281

GO:0000910

GO:0003824

GO:0004197

GO:0005515

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006508

GO:0006915

GO:0007010

GO:0007059

GO:0007127

GO:0008233

GO:0008234

GO:0012501

GO:0016787

GO:0022414

GO:0040001

GO:0043226

GO:0045143

GO:0045842

GO:0045875

GO:0051307

GO:0072686

GO:0098813

GO:0140013

GO:0140014

GO:0140096

HMNXSV003041872

ILMN_1742145

PH_hs_0009230

TC12000434.hg

g6912453_3p_at

g6912453_3p_s_at

Participates

as a component of

ESPL1 Autocleaved [cytosol] (Homo sapiens)

Other forms of this molecule

ESPL1(1-1506) [cytosol]

ESPL1(1507-1535) [cytosol]

ESPL1 [cytosol]

Inferred To

ESP1 [cytosol] (Saccharomyces cerevisiae)

cut1 [cytosol] (Schizosaccharomyces pombe)

espl1 [cytosol] (Xenopus tropicalis)

sep-1 [cytosol] (Caenorhabditis elegans)

ESPL1(1536-2120) [cytosol] (Dictyostelium discoideum)

ESPL1(1536-2120) [cytosol] (Gallus gallus)

ESPL1(1536-2120) [cytosol] (Plasmodium falciparum)

Espl1 [cytosol] (Mus musculus)

Espl1 [cytosol] (Rattus norvegicus)

ESPL1 [cytosol] (Bos taurus)

ESPL1 [cytosol] (Canis familiaris)

ESPL1 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016875742.1, XP_011537326.1, NP_036423.4, XP_006719768.1

OpenTargets

ENSG00000135476

GeneCards

Q14674

HPA

ENSG00000135476-ESPL1

Ensembl

ENST00000257934, ENSP00000257934, ENSG00000135476

PRO

Q14674

Pharos - Targets

Q14674

PDB

7NJ0, 7NJ1

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95997 PTTG1	2	K11polyUb-PTTG1 [cytosol] (R-HSA-3095943) PTTG1 [cytosol] (R-HSA-174190)	0.748	7
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.499	2
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.462	2
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.462	2

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