GSSeSG is reduced to GSSeH and GSH by GSR

Stable Identifier
R-HSA-2408542
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Glutathione reductase (GSR) homodimer is involved in the reduction of selenodiglutathione (GSSeSG) into gluthathioselenol (GSSeH) and reduced glutathione (GSH). This reaction is inferred from the event in rat (Bjornstedt et al. 1992).
Literature References
PubMed ID Title Journal Year
1569062 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase

Björnstedt, M, Holmgren, A, Kumar, S

J. Biol. Chem. 1992
Participants
Participates
Catalyst Activity

selenodiglutathione-disulfide reductase activity of GSR-2:FAD dimer [cytosol]

Inferred From
Cross References
Rhea
Authored
Reviewed
Created
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