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VTN binds Plasminogen activator inhibitor- 1
Stable Identifier
R-HSA-2396079
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
VTN binds SERPINE1
ReviewStatus
5/5
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Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)
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The somatomedin B domain of vitronectin (VTN) binds to and stabilizes plasminogen activator inhibitor-1 (PAI1) (Declerck et al. 1988). PAI1 is the principal physiological inhibitor of both tissue (tPA) and urokinase (uPA) plasminogen activators and a key regulator of the fibrinolytic system; the stabilization of PAI1 by VTN thereby regulates proteolysis of fibrin (Zhou et al. 2003). Elevated PAI1 activity is associated with coronary thrombosis (Hamsten et al. 1987) and poor prognosis in many cancers.
Literature References
PubMed ID
Title
Journal
Year
1376317
Mapping of binding sites for heparin, plasminogen activator inhibitor-1, and plasminogen to vitronectin's heparin-binding region reveals a novel vitronectin-dependent feedback mechanism for the control of plasmin formation
Stüber, W
,
Preissner, KT
,
Pannekoek, H
,
Ehrlich, HJ
,
Kost, C
J. Biol. Chem.
1992
Participants
Input
SERPINE1 [extracellular region]
(Homo sapiens)
VTN [extracellular region]
(Homo sapiens)
Output
Vitronectin:Plasminogen activator inhibitor 1 [extracellular region]
(Homo sapiens)
Participates
as an event of
ECM proteoglycans (Homo sapiens)
Orthologous Events
VTN binds Plasminogen activator inhibitor- 1 (Bos taurus)
VTN binds Plasminogen activator inhibitor- 1 (Canis familiaris)
VTN binds Plasminogen activator inhibitor- 1 (Danio rerio)
VTN binds Plasminogen activator inhibitor- 1 (Drosophila melanogaster)
VTN binds Plasminogen activator inhibitor- 1 (Mus musculus)
VTN binds Plasminogen activator inhibitor- 1 (Rattus norvegicus)
VTN binds Plasminogen activator inhibitor- 1 (Sus scrofa)
VTN binds Plasminogen activator inhibitor- 1 (Xenopus tropicalis)
Authored
Jupe, S (2013-01-10)
Reviewed
Ricard-Blum, S (2013-05-22)
Venkatesan, N (2013-05-21)
Created
Jupe, S (2012-07-09)
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