Reactome | p-T,4S-IRF3 is dimerized

p-T,4S-IRF3 is dimerized

Stable Identifier

R-HSA-2395992

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
    - STING mediated induction of host immune responses (Homo sapiens)
      - IRF3-mediated induction of type I IFN (Homo sapiens)
        
        p-T,4S-IRF3 is dimerized (Homo sapiens)
    - ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
      - IRF3 mediated activation of type 1 IFN (Homo sapiens)
        
        p-T,4S-IRF3 is dimerized (Homo sapiens)

General

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IRF3 phosphorylation promotes IRF3 dimerization and nuclear translocation, which results in the production of type I interferons (IFNs).

Literature References

PubMed ID	Title	Journal	Year
17483521	Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding Makeyeva, EN, Hargreaves, VV, Dragan, AI, Privalov, PL	Nucleic Acids Res.	2007
17526488	Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch McWhirter, SM, Maniatis, T, Harrison, SC, Panne, D	J Biol Chem	2007
11035028	Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3 ten Oever, B, Hiscott, J, Servant, MJ, LePage, C, Gessani, S, Julkunen, I, Lin, R, Conti, L	J. Biol. Chem.	2001