NOTCH1 PEST domain mutants stimulate MYC transcription

Stable Identifier
R-HSA-2220985
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 PEST domain mutants stimulate MYC transcription
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NICD1 PEST domain mutants are expected to stimulate MYC transcription in a similar manner to wild-type NICD1 (Palomero et al. 2006).
Literature References
PubMed ID Title Journal Year
17114293 NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Sulis, ML, Look, AT, Palomero, T, Soulier, J, Ferrando, AA, Real, PJ, Neuberg, D, Lim, WK, Weng, AP, Sigaux, F, Margolin, A, Young, RA, O'Neil, J, Odom, DT, Aster, JC, Califano, A, Barnes, KC

Proc Natl Acad Sci U S A 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]
Normal reaction
NOTCH1 stimulates MYC transcription (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)
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