STUB1 (CHIP) ubiquitinates SMAD3

Stable Identifier
R-HSA-2187368
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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STUB1 (CHIP) ubiquitinates SMAD3 in the absence of TGF-beta stimulation (Li et al. 2004, Xin et al. 2005).

Literature References
PubMed ID Title Journal Year
15781469 CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

Xin, H, Xu, X, Li, L, Ning, H, Rong, Y, Shang, Y, Wang, Y, Fu, XY, Chang, Z

J Biol Chem 2005
14701756 CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

Li, L, Xin, H, Xu, X, Huang, M, Zhang, X, Chen, Y, Zhang, S, Fu, XY, Chang, Z

Mol Cell Biol 2004
Participants
Participant Of
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Catalyst Activity
Title
ubiquitin-protein transferase activity of SMAD3:STUB1 [cytosol]
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Activity
Orthologous Events
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