SMAD2/3:SMAD4 complex positively regulates JUNB transcription

Stable Identifier
R-HSA-2187293
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SMAD2/3:SMAD4 heterotrimer binds SMAD binding site in the promoter of JUNB transcription factor and in cooperation with AP-1 transcription factors, which bind to an adjacent promoter element, stimulates transcription of JUNB gene (Wong et al. 1999).
Literature References
PubMed ID Title Journal Year
10022869 Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

Wong, C, Wang, XF, Datto, MB, Rougier-Chapman, EM, Li, JM, Liberati, NT, Frederick, JP

Mol Cell Biol 1999
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