Reactome | Ferriheme is transferred from Albumin to Hemopexin

Ferriheme is transferred from Albumin to Hemopexin

Stable Identifier

R-HSA-2168887

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Ferriheme is transferred from Albumin to Hemopexin

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Despite the lower affinity of ferriheme for albumin than for hemopexin, ferriheme initially associates with albumin, presumably because the molar concentration of albumin in plasma is considerably greater than that of hemopexin. Ferriheme is transferred directly from serum albumin to hemopexin (Morgan et al. 1976, Pasternack et al. 1983, Pasternack et al. 1985).

Literature References

PubMed ID	Title	Journal	Year
6849882	Hemin binding to serum proteins and the catalysis of interprotein transfer Hoeflin, E, Muller-Eberhard, U, Wong, NM, Kosar, WP, Gibbs, EJ, Pasternack, RF, Kubera, G, Skowronek, CA	Biochemistry	1983
4074707	Kinetics of hemoprotein reduction and interprotein heme transfer Muller-Eberhard, U, Wong, NM, Mauk, AG, Gibbs, EJ, Pasternack, RF, Reid, LS, Hashim, M, Kurokawa, K	Biochemistry	1985
971416	Transfer of heme from heme-albumin to hemopexin Liem, HH, Sutor, RP, Morgan, WT, Muller-Ebergard, U	Biochim Biophys Acta	1976