Reactome | 12R-HpETE is reduced to 12R-HETE by GPX1/2/4

12R-HpETE is reduced to 12R-HETE by GPX1/2/4

Stable Identifier

R-HSA-2161959

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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12R-HpETE is reduced to 12R-HETE by GPX1/2/4

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Glutathione peroxidase 1 (GPX1) (Bryant et al. 1982, Sutherland et al. 2001), 2 (GPX2) (Chu et al. 1993), and 4 (Bryant et al. 1982, Sutherland et al. 2001) are involved in converting 12R-hydroperoxy-eicosatetraenoic acid (12R-HpETE) to 12R-hydro-eicosatetraenoic acid (12R-HETE).

Literature References

PubMed ID	Title	Journal	Year
11115402	Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism Schewe, T, Shankaranarayanan, P, Nigam, S, Sutherland, M	Biochem J	2001
6816802	Role of glutathione peroxidase and hexose monophosphate shunt in the platelet lipoxygenase pathway Simon, TC, Bailey, JM, Bryant, RW	J Biol Chem	1982
8428933	Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI Esworthy, RS, Chu, FF, Doroshow, JH	J Biol Chem	1993