Reactome | EXA4 is converted to EXC4 by LTC4S

EXA4 is converted to EXC4 by LTC4S

Stable Identifier

R-HSA-2161768

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

ReviewStatus

5/5

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In addition to its role converting leukotriene A4 (LTA4) into leukotriene C4 (LTC4), the enzyme leukotriene C4 synthase (LTC4S) analogously converts eoxin A4 (EXA4), with reduced glutathione (GSH), to eoxin C4 (EXC4) (Feltenmark et al. 2008, Claesson et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18184802	Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells Griffiths, W, Brunnström, A, Edenius, C, Backman, L, Björkholm, M, Gautam, N, Lindbom, L, Claesson, HE, Feltenmark, S	Proc Natl Acad Sci U S A	2008
18647347	Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma Brunnström, A, Björkholm, M, Johnson, HA, Griffiths, WJ, Sjöberg, J, Porwit, A, Claesson, HE, Schain, F, Feltenmark, S, Andersson, E	FEBS J	2008