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CYP2C8 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-211009
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 2C8, CPC8_HUMAN
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 reactions (Homo sapiens)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Benzene is hydroxylated to phenol (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
O-atom dealkylation of dextromethorphan (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of maresins (Homo sapiens)
Biosynthesis of maresin-like SPMs (Homo sapiens)
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Homo sapiens)
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)
CYP(2) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Homo sapiens)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)
CYP(5) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10632 CYP2C8
Gene Names
CYP2C8
Chain
chain:1-490
Reference Genes
BioGPS Gene:1558 CYP2C8
COSMIC (genes):CYP2C8 CYP2C8
CTD Gene:1558 CYP2C8
dbSNP Gene:1558 CYP2C8
ENSEMBL:ENSG00000138115 CYP2C8
ENSEMBL_homo_sapiens_GENE:ENSG00000138115.15 CYP2C8
HGNC:2622 CYP2C8
KEGG Gene (Homo sapiens):1558 CYP2C8
Monarch:1558 CYP2C8
NCBI Gene:1558 CYP2C8
OMIM:601129 CYP2C8
UCSC:P10632 CYP2C8
Reference Transcript
RefSeq:NM_001198855.1 CYP2C8
RefSeq:NM_000770.3 CYP2C8
RefSeq:NM_001198853.1 CYP2C8
RefSeq:NM_001198854.1 CYP2C8
Other Identifiers
11728250_s_at
11747879_a_at
11750452_a_at
1175_s_at
1558
16716751
208147_PM_s_at
208147_s_at
3258984
3259054
3301142
3301143
3301145
3301148
3301149
3301150
3301151
3301152
3301153
3301156
3301160
3301164
3301165
3301166
38548_at
7935169
A_23_P161368
GE57852
GO:0002933
GO:0003824
GO:0004497
GO:0005506
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006082
GO:0006629
GO:0006805
GO:0008202
GO:0008210
GO:0008392
GO:0008401
GO:0016020
GO:0016491
GO:0016705
GO:0016712
GO:0019369
GO:0019373
GO:0020037
GO:0034875
GO:0042178
GO:0042572
GO:0042573
GO:0042759
GO:0043226
GO:0043231
GO:0046456
GO:0046872
GO:0070330
GO:0070989
GO:0097267
GO:0101020
HMNXSV003007823
HMNXSV003019324
ILMN_1769155
PH_hs_0023456
TC10001546.hg
g13787186_3p_s_at
Participates
as a member of
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP(5) [endoplasmic reticulum membrane] (Homo sapiens)
CYP(2) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Cyp2c66 [endoplasmic reticulum membrane]
(Mus musculus)
Cyp2c66 [endoplasmic reticulum membrane]
(Rattus norvegicus)
cyp-33d1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33d3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Cyp2c65 [endoplasmic reticulum membrane]
(Mus musculus)
cyp-35a2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-35a1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-35a5 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-35a3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-35a4 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C49 [endoplasmic reticulum membrane]
(Sus scrofa)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Bos taurus)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Mus musculus)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Sus scrofa)
cyp-33c5 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c12 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c7 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33e2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-34a1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33b1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C293 [endoplasmic reticulum membrane]
(Sus scrofa)
cyp-34a9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-35b2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C297 [endoplasmic reticulum membrane]
(Sus scrofa)
cyp-34a5 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-34a7 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C88 [endoplasmic reticulum membrane]
(Bos taurus)
dach-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C85 [endoplasmic reticulum membrane]
(Bos taurus)
cyp-34a10 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C87 [endoplasmic reticulum membrane]
(Bos taurus)
cyp-33a1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
daf-9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-35c1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c11 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c4 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c8 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C19 [endoplasmic reticulum membrane]
(Bos taurus)
CYP2C19 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C19 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP2C19 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
CYP2C19 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP2C19 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP2C90 [endoplasmic reticulum membrane]
(Bos taurus)
cyp-33e1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C301 [endoplasmic reticulum membrane]
(Sus scrofa)
cyp-33e3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-34a2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-35b1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-34a8 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-35b3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-34a6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-23a1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000761.3
,
NP_001185783.1
,
NP_001185784.1
,
NP_001185782.1
ZINC - World Drugs
CP2C8_HUMAN
Guide to Pharmacology - Targets
1325
OpenTargets
ENSG00000138115
ZINC - FDA approved
CP2C8_HUMAN
ZINC - Substances
CP2C8_HUMAN
ZINC target
P10632
ZINC - Biogenic
CP2C8_HUMAN
PRO
P10632
PDB
2VN0
,
1PQ2
,
2NNI
,
2NNH
,
2NNJ
ZINC - Investigational
CP2C8_HUMAN
ZINC - Metabolites
CP2C8_HUMAN
HPA
ENSG00000138115-CYP2C8
GeneCards
P10632
Ensembl
ENSP00000360317
,
ENSP00000445062
,
ENST00000535898
,
ENSG00000138115
,
ENST00000371270
Pharos - Targets
P10632
Orphanet
24452
ZINC - Predictions - Purchasable
CP2C8_HUMAN
HMDB Protein
HMDBP01562
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