Reactome | Interaction of PECAM-1 and PLC gamma1

Interaction of PECAM-1 and PLC gamma1

Stable Identifier

R-HSA-210283

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Like SHP-1 and SHP-2, PLC-gamma 1 also interacts with PECAM-1. PLC-gamma 1 binds with both the tyrosine residues (Y663 and Y686). Unlike the N-SH2 domain, the C-SH2 domain on PLC-gamma 1 can only bind phosphotyrosine 663. The engagement of PECAM-1 with PLC-gamma 1 may lead to PLC-gamma 1 activation and subsequent calcium influx.

Literature References

PubMed ID	Title	Journal	Year
10350061	Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31 Pumphrey, NJ, Buckley, CD, Douglas, MR, Taylor, V, Lord, JM, Salmon, M, Bird, IN, Young, SP, Wakelam, MJ, Bradfield, PF, Freeman, S	FEBS Lett	1999