Reactome | STIM1 binds TRPC1 forming STIM1:TRPC1 complex

STIM1 binds TRPC1 forming STIM1:TRPC1 complex

Stable Identifier

R-HSA-2089927

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, plasma membrane

Synonyms

STIM1 Binds TRPC1

ReviewStatus

5/5

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STIM1 binds TRPC1 forming STIM1:TRPC1 complex

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The polybasic region of STIM1 interacts with 2 aspartate residues in the C-terminal region of TRPC1 (Zeng et al. 2008, Huang et al. 2006). The STIM1:TRPC1 complex can form a tenary complex with ORAI1 (Ong et al. 2007, Jardin et al. 2008) and ORAI participates in function of STIM1:TRPC1 channels (Cheng et al. 2008, Cheng et al. 2011). As inferred from chicken DT40 cells, TRPC1 (and possibly other TRP channels) participates in store-operated calcium influx during signaling by the B cell receptor (Mori et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
18420269	STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts Alfonso, S, Angélica, Z, Vaca, L, Alicia, S, Carlos, S	Cell Calcium	2008
18995841	STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction Yuan, JP, Muallem, S, Kim, MS, Huang, GN, Choi, YJ, Zeng, W, Worley, PF	Mol Cell	2008
17486119	STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels Yuan, JP, Muallem, S, Huang, GN, Zeng, W, Worley, PF	Nat Cell Biol	2007
16906149	STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels Yuan, JP, Muallem, S, Huang, GN, Zeng, W, Han, L, Kim, JY, Worley, PF	Nat Cell Biol	2006
18326500	Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels Ong, HL, Ambudkar, IS, Liu, X, Cheng, KT	J Biol Chem	2008
11901194	Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes Iino, M, Kurosaki, M, Gotoh, K, Hara, Y, Okada, T, Kurosaki, T, Miyakawa, T, Hirose, K, Mizushima, A, Nishida, M, Penner, R, Wakamori, M, Fleig, A, Mori, Y, Hermosura, M, Mori, E	J Exp Med	2002
22210847	The Ca2+ Sensor STIM1 is Necessary and Sufficient for the Store-Operated Ca2+ Entry Function of TRPCs in Endothelial Cells Freichel, M, Tiruppathi, C, Yuan, JP, Malik, AB, Vogel, SM, Sundivakkam, PC, Flockerzi, V, Singh, V	Mol Pharmacol	2011
18843204	Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1 Jardin, I, Rosado, JA, Salido, GM	Channels (Austin)	2008
17224452	Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components Gwack, Y, Ong, HL, Bandyopadhyay, BC, Ambudkar, IS, Srikanth, S, Liu, X, Singh, BB, Pani, B, Paria, BC, Gill, DL, Soboloff, J, Cheng, KT	J Biol Chem	2007
21408196	Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions Swaim, W, Ong, HL, Ambudkar, IS, Liu, X, Cheng, KT	PLoS Biol	2011