Reactome | Dimerization of KIT upon SCF binding

Dimerization of KIT upon SCF binding

Stable Identifier

R-HSA-205231

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Binding of the SCF dimer to KIT rapidly triggers KIT dimerization and autophosphorylation. It is thought that one SCF dimer binds simultaneously to two KIT monomers. The fourth Ig-like domain of KIT contains the dimerisation site; deletion of this domain completely abolishes KIT dimerisation and subsequent downstream signaling (Edling et al. 2007, Blechman et al. 1995). KIT dimerization is a crucial initial step in the SCF signal transduction process.

Literature References

PubMed ID	Title	Journal	Year
8636116	Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit Wypych, J, Schwartz, MG, Langley, KE, Wen, J, Mendiaz, EA, Philo, JS	J Biol Chem	1996
9446650	Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer Kavanagh, TJ, Komatsu, N, Bühring, HJ, Broudy, VC, Lin, NL	Blood	1998
9045650	Kit receptor dimerization is driven by bivalent binding of stem cell factor Schlessinger, J, Pinchasi, D, Zhou, M, Lax, I, Lemmon, MA	J Biol Chem	1997
17255936	Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases Liu, H, Chen, X, He, X, Focia, PJ	EMBO J	2007