p75NTR:NADE promotes caspase2/3 activation

Stable Identifier
R-HSA-205117
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once bound to the NGF:p75NTR complex, NADE contributes to cell death signalling by promoting activation of caspases 2 and 3. It is unclear whether JNK activation is involved. The apoptotic function of NADE was observed in oligodendrocytes (Mukai et al. 2002).

Literature References
PubMed ID Title Journal Year
11830582 Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis

Mukai, J, Shoji, S, Kimura, MT, Okubo, S, Sano, H, Suvanto, P, Li, Y, Irie, S, Sato, TA

J Biol Chem 2002
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activator activity involved in apoptotic process of NGF:p75NTR:NADE [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created