Interaction of Tie2 and Shp2

Stable Identifier
R-HSA-204873
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Interaction of Tie2 and Shp2
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Shp2 interact with Tyr816 in the juxtamembrane region and Tyr1108 and Tyr1113, respectively, in the C-terminal tail region of Tie2/Tek.
Literature References
PubMed ID Title Journal Year
10521483 Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.

Alitalo, K, Daly, R, Bouchard, D, Jones, J, Master, Z, Sasaki, H, Gunji, Y, Dumont, DJ, Jones, N

J Biol Chem 1999
9764820 The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

Dumont, DJ, Jones, N

Oncogene 1998
Participants
Input
Output
Participates
as an event of
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Interaction of Tie2 and Shp2 (Rattus norvegicus)
Interaction of Tie2 and Shp2 (Sus scrofa)
Interaction of Tie2 and Shp2 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-03-05)
de Bono, B  (2008-03-05)
Reviewed
Trowsdale, J  (2009-02-13)
Created
Garapati, P V  (2007-12-03)
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