Interaction of Tie2 with Ang2

Stable Identifier
R-HSA-204863
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The major ligands for Tie2 are Ang1 and Ang2. Ang1 has been considered as the primary activating ligand of Tie2 whereas role of Ang2 remains controversial. Ang2 acts as stimulating in some studies and inhibiting in others. The activity of Ang2 is concentration dependent. Ang2 possesses similar receptor affinity to Ang1 and they both share the same binding site on Tie2. The Ang2 fibrinogen domain is solely responsible for receptor recognition and binding, the coiled-coil motif mediates its oligomerization.

Literature References
PubMed ID Title Journal Year
15893672 Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition

Barton, WA, Tzvetkova, D, Nikolov, DB

Structure 2005
16895971 Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization

Bogdanovic, E, Nguyen, VP, Dumont, DJ

J Cell Sci 2006
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