Reactome | Interaction of Tie2 and Grb14

Interaction of Tie2 and Grb14

Stable Identifier

R-HSA-204813

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Grb14 is also one of the signaling partners of Tie2. The SH2 domain of Grb2 mediates binding to Tie2. It binds residues Y816, Y1108 and Y1113 respectively, in the C-terminal tail region of Tie2/Tek.

Literature References

PubMed ID	Title	Journal	Year
10521483	Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. Alitalo, K, Daly, R, Bouchard, D, Jones, J, Master, Z, Sasaki, H, Gunji, Y, Dumont, DJ, Jones, N	J Biol Chem	1999
11607834	The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions Han, DC, Guan, JL, Shen, TL	Oncogene	2001