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SLIT1 [extracellular region]
Stable Identifier
R-HSA-204359
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Slit homolog 1 protein, SLT1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
DCC interaction with ROBO1 (Homo sapiens)
DCC:ROBO1:SLIT [plasma membrane] (Homo sapiens)
ROBO1:SLIT [plasma membrane] (Homo sapiens)
SLIT [extracellular region] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
ROBO1:SLIT [plasma membrane] (Homo sapiens)
SLIT [extracellular region] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
ROBO1 binds FLRT3 (Homo sapiens)
SLIT1:ROBO1 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
SLIT1:ROBO1:FLRT3 [plasma membrane] (Homo sapiens)
SLIT1:ROBO1 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
Regulation of commissural axon pathfinding by SLIT and ROBO (Homo sapiens)
DCC interaction with ROBO1 (Homo sapiens)
DCC:ROBO1:SLIT [plasma membrane] (Homo sapiens)
ROBO1:SLIT [plasma membrane] (Homo sapiens)
SLIT [extracellular region] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
ROBO1:SLIT [plasma membrane] (Homo sapiens)
SLIT [extracellular region] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
Regulation of cortical dendrite branching (Homo sapiens)
NCK2 binds to ROBO1,(ROBO2) (Homo sapiens)
SLIT1:ROBO1,ROBO2 [plasma membrane] (Homo sapiens)
SLIT1:ROBO1 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
SLIT1:ROBO2 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
SLIT1:ROBO1,ROBO2:NCK2 [plasma membrane] (Homo sapiens)
SLIT1:ROBO1,ROBO2 [plasma membrane] (Homo sapiens)
SLIT1:ROBO1 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
SLIT1:ROBO2 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
SLIT1 binds ROBO1,(ROBO2) (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
SLIT1:ROBO1,ROBO2 [plasma membrane] (Homo sapiens)
SLIT1:ROBO1 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
SLIT1:ROBO2 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
SLIT1 binds COL4A5 (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
SLIT1:COL4A5 [plasma membrane] (Homo sapiens)
SLIT1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75093 SLIT1
Gene Names
SLIT1, KIAA0813, MEGF4, SLIL1
Chain
signal peptide:1-33, chain:34-1534
Reference Genes
BioGPS Gene:6585 SLIT1
COSMIC (genes):SLIT1 SLIT1
CTD Gene:6585 SLIT1
dbSNP Gene:6585 SLIT1
ENSEMBL:ENSG00000187122 SLIT1
ENSEMBL_homo_sapiens_GENE:ENSG00000187122.17 SLIT1
HGNC:11085 SLIT1
KEGG Gene (Homo sapiens):6585 SLIT1
Monarch:6585 SLIT1
NCBI Gene:6585 SLIT1
OMIM:603742 SLIT1
UCSC:O75093 SLIT1
Reference Transcript
RefSeq:NM_003061.2 SLIT1
Other Identifiers
11728890_at
11728891_at
16717032
208221_PM_s_at
208221_s_at
213601_PM_at
213601_at
3302057
3302058
3302059
3302060
3302061
3302062
3302063
3302065
3302066
3302067
3302068
3302069
3302070
3302071
3302072
3302074
3302075
3302076
3302081
3302083
3302084
3302085
3302086
3302087
3302092
3302093
3302094
3302095
3302096
3302097
3302099
3302100
3302102
3302104
3302105
3302106
3302107
3302108
3302111
3302150
3302152
3302153
3302163
3302164
37849_at
63748_f_at
6585
7935361
A_23_P161386
A_24_P940644
A_33_P3411035
GE53312
GE893151
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0007097
GO:0007399
GO:0007409
GO:0007411
GO:0008045
GO:0008201
GO:0016043
GO:0021510
GO:0021772
GO:0022028
GO:0022029
GO:0030154
GO:0031290
GO:0033563
GO:0034330
GO:0043395
GO:0048495
GO:0048812
GO:0048843
GO:0048846
GO:0048853
GO:0048856
GO:0048870
GO:0050919
GO:0051964
HMNXSV003032122
Hs.133466.1.S1_3p_at
ILMN_1756959
PH_hs_0008038
TC10002951.hg
g4507060_3p_a_at
Participates
as a member of
SLIT [extracellular region] (Homo sapiens)
as a component of
SLIT1:COL4A5 [plasma membrane] (Homo sapiens)
SLIT1:ROBO1 [plasma membrane] (Homo sapiens)
SLIT1:ROBO2 [plasma membrane] (Homo sapiens)
as an input of
SLIT1 binds COL4A5 (Homo sapiens)
SLIT1 binds ROBO1,(ROBO2) (Homo sapiens)
Cross References
RefSeq
NP_003052.2
OpenTargets
ENSG00000187122
HPA
ENSG00000187122-SLIT1
GeneCards
O75093
Ensembl
ENST00000266058
,
ENSG00000187122
,
ENSP00000266058
PRO
O75093
Pharos - Targets
O75093
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.666
4
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q6WN34-2 CHRDL2
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q6ZNG0 ZNF620
1
ZNF620 [nucleoplasm]
(R-HSA-2127603)
0.556
3
UniProt:Q5TD97 FHL5
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q3SY46 KRTAP13-3
1
KRTAP13-3 [cytosol]
(R-HSA-6810267)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q52LG2 KRTAP13-2
1
KRTAP13-2 [cytosol]
(R-HSA-6810274)
0.556
3
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