Caspase mediated cleavage of beta-catenin

Stable Identifier
R-HSA-202969
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Apoptosis-induced cleavage of beta-catenin by caspase 3 results in reduced alpha catenin binding, relocalization to the cytoplasm and a reduction in cell-cell contact. In addition, the resulting proteolytic fragments have reduced transcription factor activity (Steinhusen et al., 2000 ).

Literature References
PubMed ID Title Journal Year
10748026 Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential

Steinhusen, U, Badock, V, Bauer, A, Behrens, J, Wittman-Liebold, B, Dorken, B, Bommert, K

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created