Reactome | FCGR activation

FCGR activation

Stable Identifier

R-HSA-2029481

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Cross-linking of FCGRs with IgG coated immune complexes results in tyrosine phosphorylation of the immuno tyrosine activation motif (ITAMs) of the rececptor by membrane-bound tyrosine kinases of the SRC family. The phosphorylated ITAM tyrosines serve as docking sites for Src homology 2 (SH2) domain-containing SYK kinase. Recruitment and activation of SYK is critical for FCGR-mediated signaling in phagocytosis, but the exact role of SYK in this process is unclear. Activated SYK then transmits downstream signals leading to actin polymerization and particle internalization.

Literature References

PubMed ID	Title	Journal	Year
12488490	Signal transduction during Fc receptor-mediated phagocytosis Rosales, C, García-García, E	J Leukoc Biol	2002
17050193	Fcgamma receptor signaling in phagocytes Tridandapani, S, Joshi, T, Butchar, JP	Int J Hematol	2006
18322649	Molecular mechanisms of phagocytic uptake in mammalian cells Dart, AE, Caron, E, Groves, E, Covarelli, V	Cell Mol Life Sci	2008