Caspase-mediated cleavage of Desmoglein 1

Stable Identifier
R-HSA-202917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Caspase mediated cleavage of desmoglein 1 leads to decreased expression at the cell surface and re-localization of its C terminus diffusely throughout the cytoplasm. Cleavage is thought to contribute to the dismantling of desmosomes during keratinocyte apoptosis (Dusek et al., 2006).

Literature References
PubMed ID Title Journal Year
16286477 The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes

Dusek, RL, Getsios, S, Chen, F, Park, JK, Amargo, EV, Cryns, VL, Green, KJ

J Biol Chem 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created