Reactome | DCTN4 [cytosol]

DCTN4 [cytosol]

Stable Identifier

R-HSA-2029070

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynactin subunit 4, DCTN4_HUMAN

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
      - Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - MHC class II antigen presentation (Homo sapiens)
    - Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
      - Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
      - Kinesins:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-independent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin rod [cytosol] (Homo sapiens)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
        
        Pointed end complex [cytosol] (Homo sapiens)
        
        DCTN4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJW0 DCTN4

Gene Names

DCTN4

Chain

initiator methionine:, chain:2-460

Reference Genes

BioGPS Gene:51164 DCTN4

COSMIC (genes):DCTN4 DCTN4

CTD Gene:51164 DCTN4

dbSNP Gene:51164 DCTN4

ENSEMBL:ENSG00000132912 DCTN4

ENSEMBL_homo_sapiens_GENE:ENSG00000132912.13 DCTN4

HGNC:15518 DCTN4

KEGG Gene (Homo sapiens):51164 DCTN4

Monarch:51164 DCTN4

NCBI Gene:51164 DCTN4

OMIM:614758 DCTN4

UCSC:Q9UJW0 DCTN4

Reference Transcript

Other Identifiers

11718742_s_at

11734569_a_at

11734570_s_at

11734571_x_at

11749838_a_at

11751475_a_at

17001718

218013_PM_x_at

218013_x_at

222488_PM_s_at

222488_s_at

233490_PM_at

233490_at

2881555

2881556

2881557

2881558

2881559

2881560

2881561

2881563

2881564

2881565

2881569

2881572

2881574

2881576

2881577

2881579

2881580

2881581

2881583

2881584

2881585

2881586

43847_s_at

51164

65917_at

73429_at

8115181

83502_at

A_23_P251945

GE55433

GO:0000776

GO:0000922

GO:0001725

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005868

GO:0005869

GO:0005925

GO:0005938

GO:0030017

GO:0043226

HMNXSV003017364

Hs.180952.0.A2_3p_a_at

Hs.180952.2.A1_3p_a_at

PH_hs_0016236

TC05001943.hg

g7705892_3p_a_at

Participates

as a component of

Pointed end complex [cytosol] (Homo sapiens)

Inferred To

dnc-4 [cytosol] (Caenorhabditis elegans)

Dctn4 [cytosol] (Mus musculus)

Dctn4 [cytosol] (Rattus norvegicus)

dynD [cytosol] (Dictyostelium discoideum)

DCTN4 [cytosol] (Bos taurus)

DCTN4 [cytosol] (Canis familiaris)

DCTN4 [cytosol] (Gallus gallus)

DCTN4 [cytosol] (Plasmodium falciparum)

DCTN4 [cytosol] (Sus scrofa)

dctn4 [cytosol] (Xenopus tropicalis)

DCTN4-p62 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_057305.1, XP_011535946.1, NP_001129115.1, XP_011535947.1, NP_001129116.1

OpenTargets

ENSG00000132912

GeneCards

Q9UJW0

HPA

ENSG00000132912-DCTN4

Ensembl

ENSG00000132912, ENSP00000416968, ENST00000424236, ENST00000447998, ENST00000446090, ENSP00000411251, ENSP00000414906

PRO

Q9UJW0

Pharos - Targets

Q9UJW0

Orphanet

21303

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.781	7
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.619	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3

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