Reactome | STX4 [phagocytic vesicle membrane]

STX4 [phagocytic vesicle membrane]

Stable Identifier

R-HSA-2029044

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagocytic vesicle membrane

Synonyms

Syntaxin 4

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q12846 STX4

Gene Names

STX4, STX4A

Chain

chain:1-297

Reference Genes

BioGPS Gene:6810 STX4

COSMIC (genes):STX4 STX4

CTD Gene:6810 STX4

dbSNP Gene:6810 STX4

ENSEMBL:ENSG00000103496 STX4

HGNC:11439 STX4

KEGG Gene (Homo sapiens):6810 STX4

Monarch:6810 STX4

NCBI Gene:6810 STX4

OMIM:186591 STX4

UCSC:Q12846 STX4

Reference Transcript

Other Identifiers

0000580551

11725677_a_at

1330

16818125

203530_s_at

3656761

3656762

3656763

3656764

3656765

3656766

3656767

3656768

3656770

3656772

3656774

3656775

3656776

3656777

3656779

3656781

3656782

37911_at

6810

7995017

A_23_P256375

AAA20967

AAB88810

AAG40313

AAH02436

AAP35990

AC135050

AF026007

AF318489

AJ000541

AK091833

AK315716

BAG38075

BAG52424

BC002436

BT007326

C9JFM5

CAA04174

CAA59769

CAG46605

CCDS10700

CCDS61916

CH471192

CR541806

EAW52176

EAW52177

ENSG00000103496

ENSP00000317714

ENSP00000378447

ENST00000313843

ENST00000313843.7

ENST00000394998

ENST00000394998.5

EntrezGene:6810

EntrezGene:STX4

g4759185_3p_a_at

GE58889

GO:0000149

GO:0000322

GO:0002376

GO:0003674

GO:0005484

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005773

GO:0005794

GO:0005802

GO:0005829

GO:0005886

GO:0006810

GO:0006836

GO:0006886

GO:0006887

GO:0006892

GO:0006906

GO:0006950

GO:0007155

GO:0007165

GO:0007267

GO:0008021

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009986

GO:0012505

GO:0016020

GO:0016021

GO:0016192

GO:0016230

GO:0016323

GO:0017157

GO:0019221

GO:0022607

GO:0030027

GO:0030234

GO:0030335

GO:0030670

GO:0031201

GO:0031410

GO:0031629

GO:0032991

GO:0033194

GO:0035493

GO:0035749

GO:0035774

GO:0036477

GO:0040011

GO:0042581

GO:0042592

GO:0042734

GO:0043085

GO:0043197

GO:0043219

GO:0043226

GO:0043311

GO:0045202

GO:0045335

GO:0045785

GO:0048278

GO:0048284

GO:0048471

GO:0048787

GO:0048870

GO:0050921

GO:0051024

GO:0060291

GO:0061024

GO:0065003

GO:0070062

GO:0071346

GO:0098794

GO:0098978

GO:1902041

GO:1903078

GO:1990668

GO:2000010

H3BMK2

HGNC:11439

HPA001330

ILMN_1680313

IPR000727

IPR006011

IPR006012

IPR010989

MIM:186591

NM_001272095

NM_001272096

NM_004604

NP_001259024

NP_001259025

NP_004595

PF00804

PF05739

PH_hs_0004775

SM00397

SM00503

STX4

STX4-201

STX4-202

TC16000366.hg

U07158

U07158_at

UPI0000136162

UPI00003E28D4

X85784

XM_005255521

XP_005255578

XR_002957836

XR_002957837

Participant Of

hasComponent

input

SEC22B, CALR, STX4, TAP and TAPBP bind

Other forms of this molecule

STX4 [plasma membrane]

STX4 [cytosol]

p-STX4 [cytosol]

Inferred To

STX4 [phagocytic vesicle membrane] (Bos taurus)

STX4 [phagocytic vesicle membrane] (Caenorhabditis elegans)

STX4 [phagocytic vesicle membrane] (Canis familiaris)

STX4 [phagocytic vesicle membrane] (Danio rerio)

STX4 [phagocytic vesicle membrane] (Dictyostelium discoideum)

STX4 [phagocytic vesicle membrane] (Drosophila melanogaster)

STX4 [phagocytic vesicle membrane] (Mus musculus)

STX4 [phagocytic vesicle membrane] (Rattus norvegicus)

STX4 [phagocytic vesicle membrane] (Sus scrofa)

STX4 [phagocytic vesicle membrane] (Xenopus tropicalis)

Ghost homologue of STX4 [phagocytic vesicle membrane] (Gallus gallus)

Homologues of STX4 [phagocytic vesicle membrane] (Caenorhabditis elegans)

Homologues of STX4 [phagocytic vesicle membrane] (Dictyostelium discoideum)

Homologues of STX4 [phagocytic vesicle membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001259025.1, NP_004595.2

OpenTargets

ENSG00000103496

GeneCards

Q12846

PRO

Q12846

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15836 VAMP3	6	VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.837	8
UniProt:O43752 STX6	2	STX6 [Golgi membrane] (R-HSA-6811004) STX6 [trans-Golgi network membrane] (R-HSA-6811007)	0.818	7
UniProt:Q53TN4 CYBRD1	1	CYBRD1 [plasma membrane] (R-HSA-917788)	0.781	7
UniProt:Q86Y82 STX12			0.766	6
UniProt:O95183 VAMP5			0.766	8
UniProt:O15400 STX7			0.764	6
UniProt:O75379 VAMP4	4	VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.764	6
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [cytosol] (R-HSA-9613991)	0.696	5
UniProt:Q9UNK0 STX8			0.696	5
UniProt:O15155 BET1	3	BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743) BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142)	0.696	5
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.696	5
UniProt:Q9UEU0 VTI1B	2	VTI1B [platelet alpha granule lumen] (R-HSA-8862964) VTI1B [extracellular region] (R-HSA-8862983)	0.696	5
UniProt:P63027 VAMP2	23	VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372517) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-265198) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-375436) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129)	0.696	5
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [Golgi membrane] (R-HSA-6807755) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800)	0.696	5
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.696	5
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.696	5
UniProt:O75379-2 VAMP4			0.666	4
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.635	3
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.632	3
UniProt:Q8TGQ7 YP159			0.556	3
UniProt:Q5SQN1 SNP47			0.556	3
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.556	3
UniProt:Q96F15 GIMA5			0.556	3
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.556	3
UniProt:P25385	4	GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-SCE-5689800) GOSR2 [endoplasmic reticulum membrane] (R-SCE-5689451) GOSR2 [Golgi membrane] (R-SCE-6807755)	0.556	3
UniProt:P23763 VAMP1	7	VAMP1(1-83) [cytosol] (R-HSA-5250967) VAMP1(84-118) [synaptic vesicle membrane] (R-HSA-5250991) VAMP1(1-61) [cytosol] (R-HSA-2976003) VAMP1(62-118) [synaptic vesicle membrane] (R-HSA-5250599) VAMP1(1-60) [cytosol] (R-HSA-2976004) VAMP1(61-118) [synaptic vesicle membrane] (R-HSA-5250888) VAMP1 [synaptic vesicle membrane] (R-HSA-2976040)	0.556	3
UniProt:P38736	1	GOSR1 [Golgi membrane] (R-SCE-6807753)	0.556	3
UniProt:Q08144	2	STX17 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-6807769) STX16 [trans-Golgi network membrane] (R-SCE-6811002)	0.556	3
UniProt:O14662 STX16	2	STX16 [trans-Golgi network membrane] (R-HSA-6811002) STX16 [Golgi membrane] (R-HSA-6811001)	0.556	3
UniProt:P23763-3 VAMP1			0.488	2
UniProt:O60499-2 STX10			0.488	2
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.488	2
UniProt:Q8TDT2 GP152			0.488	2
UniProt:Q969S6 TM203			0.488	2
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.488	2
UniProt:O75558 STX11			0.488	2
UniProt:P60201-2 PLP1			0.488	2
UniProt:Q9Y228 T3JAM			0.488	2
UniProt:Q8N511 TM199			0.488	2
UniProt:Q8N8B7-2 TCEANC			0.488	2
UniProt:P32856-2 STX2			0.488	2
UniProt:P61266 STX1B	3	STX1B(?-288) [plasma membrane] (R-HSA-5246519) STX1B(1-?) [cytosol] (R-HSA-5246520) STX1B [plasma membrane] (R-HSA-181479)	0.488	2
UniProt:O14662-5 STX16			0.488	2
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.488	2
UniProt:G2XKQ0 SUMO5			0.488	2
UniProt:O95159 ZFPL1			0.488	2
UniProt:Q96IV6 FXDC2			0.488	2
UniProt:Q9NYB9-2 ABI2			0.488	2
UniProt:Q86W74-2 ANKRD46			0.488	2
UniProt:Q16623 STX1A	6	STX1A [plasma membrane] (R-HSA-6794231) STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.488	4
UniProt:Q9Y6X1 SERP1	2	SERP1 [cytosol] (R-HSA-5250574) SERP1 [endoplasmic reticulum membrane] (R-HSA-381045)	0.488	2
UniProt:P21926 CD9	4	CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [plasma membrane] (R-HSA-51717) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2