Reactome | DNM2 [endocytic vesicle membrane]

DNM2 [endocytic vesicle membrane]

Stable Identifier

R-HSA-2029000

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

Dynamin-2, DYN2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P50570 DNM2

Gene Names

DNM2, DYN2

Chain

chain:1-870

Reference Genes

BioGPS Gene:1785 DNM2

COSMIC (genes):DNM2 DNM2

CTD Gene:1785 DNM2

dbSNP Gene:1785 DNM2

ENSEMBL:ENSG00000079805 DNM2

HGNC:2974 DNM2

KEGG Gene (Homo sapiens):1785 DNM2

Monarch:1785 DNM2

NCBI Gene:1785 DNM2

OMIM:602378 DNM2

UCSC:P50570 DNM2

Reference Transcript

Other Identifiers

0002030053

11735759_a_at

11741014_x_at

11749116_a_at

1785

202253_s_at

2YS1

32622_at

3820759

3820760

3820771

3820777

3820779

3820780

3820781

3820782

3820784

3820786

3820789

3820795

3820797

3820803

3820809

3820813

3820816

3820818

3820820

3820821

3820825

3820827

3820828

3820830

3820831

3820832

54246

8025741

A_23_P407074

AAA88025

AAD23604

AAH39596

AAH54501

AC007229

AC011475

AC011552

AC011554

AC112707

AK289831

AK312260

BAF82520

BC039596

BC054501

CCDS32907

CCDS32908

CCDS45968

CCDS45969

CCDS59351

DNM2

DNM2-201

DNM2-202

DNM2-203

DNM2-204

DNM2-205

ENSG00000079805

ENSP00000347890

ENSP00000352721

ENSP00000373905

ENSP00000386192

ENSP00000468734

ENST00000355667

ENST00000355667.10

ENST00000359692

ENST00000359692.10

ENST00000389253

ENST00000389253.8

ENST00000408974

ENST00000408974.8

ENST00000585892

ENST00000585892.5

EntrezGene:1785

EntrezGene:DNM2

g4826699_3p_a_at

GE57744

GO:0000003

GO:0000086

GO:0000139

GO:0000166

GO:0000266

GO:0000278

GO:0000902

GO:0001891

GO:0001917

GO:0002031

GO:0002376

GO:0003281

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005768

GO:0005794

GO:0005802

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005905

GO:0005925

GO:0006355

GO:0006810

GO:0006893

GO:0006897

GO:0006898

GO:0006909

GO:0006950

GO:0007005

GO:0007009

GO:0007049

GO:0007165

GO:0007283

GO:0008017

GO:0008092

GO:0008150

GO:0008219

GO:0009058

GO:0009416

GO:0010592

GO:0014069

GO:0015031

GO:0016020

GO:0016185

GO:0016192

GO:0016787

GO:0017124

GO:0019886

GO:0019899

GO:0019901

GO:0022607

GO:0030027

GO:0030054

GO:0030154

GO:0030424

GO:0030426

GO:0030496

GO:0030512

GO:0030516

GO:0030666

GO:0030670

GO:0031410

GO:0031623

GO:0031749

GO:0032587

GO:0032991

GO:0033572

GO:0034641

GO:0035020

GO:0035904

GO:0036312

GO:0040007

GO:0042220

GO:0042995

GO:0043065

GO:0043167

GO:0043197

GO:0043226

GO:0044327

GO:0044351

GO:0044877

GO:0045202

GO:0045211

GO:0045334

GO:0045429

GO:0045807

GO:0045893

GO:0048471

GO:0048488

GO:0048489

GO:0048812

GO:0048856

GO:0050699

GO:0050766

GO:0050803

GO:0050998

GO:0050999

GO:0055085

GO:0060976

GO:0061024

GO:0070062

GO:0071245

GO:0071481

GO:0071732

GO:0098793

GO:0098844

GO:0098884

GO:0098978

GO:0099092

GO:1900026

GO:1902856

GO:1903351

GO:1903358

GO:1903408

GO:1903526

GO:2000370

HGNC:2974

HPA054246

ILMN_1656822

ILMN_2339377

IPR000375

IPR001401

IPR001849

IPR003130

IPR011993

IPR019762

IPR020850

IPR022812

IPR027188

IPR027417

IPR030381

K7EMQ3

K7EMR9

K7EPK9

L36983

L36983_at

LRG_238

LRG_238t1

LRG_238t2

MIM:160150

MIM:602378

MIM:606482

MIM:615368

NM_001005360

NM_001005361

NM_001005362

NM_001190716

NM_004945

NP_001005360

NP_001005361

NP_001005362

NP_001177645

NP_004936

PF00169

PF00350

PF01031

PF02212

PH_hs_0025257

PR00195

SM00053

SM00233

SM00302

TC19002623.hg

UPI00001B0788

UPI0000203350

UPI000049A626

UPI000049A627

UPI0001DAFE3F

Participant Of

hasComponent

eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane]

Other forms of this molecule

DNM2 [plasma membrane]

DNM2 [cytosol]

DNM2 [lysosomal membrane]

DNM2 [Golgi membrane]

Inferred To

DNM2 [endocytic vesicle membrane] (Bos taurus)

DNM2 [endocytic vesicle membrane] (Caenorhabditis elegans)

DNM2 [endocytic vesicle membrane] (Canis familiaris)

DNM2 [endocytic vesicle membrane] (Danio rerio)

DNM2 [endocytic vesicle membrane] (Dictyostelium discoideum)

DNM2 [endocytic vesicle membrane] (Drosophila melanogaster)

DNM2 [endocytic vesicle membrane] (Mus musculus)

DNM2 [endocytic vesicle membrane] (Rattus norvegicus)

DNM2 [endocytic vesicle membrane] (Saccharomyces cerevisiae)

DNM2 [endocytic vesicle membrane] (Schizosaccharomyces pombe)

DNM2 [endocytic vesicle membrane] (Sus scrofa)

DNM2 [endocytic vesicle membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001005361.1, NP_001177645.1, NP_001005362.1, NP_001005360.1, NP_004936.2

OpenTargets

ENSG00000079805

ZINC - Substances

DYN2_HUMAN

GeneCards

P50570

ZINC target

P50570

PRO

P50570

Orphanet

15882

ZINC - Predictions - Purchasable

DYN2_HUMAN

PDB

2YS1

HMDB Protein

HMDBP08364

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.886	7
UniProt:Q9Y5X1 SNX9	3	SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytosol] (R-HSA-8867737) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.807	8
UniProt:Q99962 SH3GL2	4	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [cytosol] (R-HSA-182958)	0.722	4
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.713	3
UniProt:P49418 AMPH	1	AMPH [cytosol] (R-HSA-8867728)	0.713	3
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.645	5
UniProt:P22392 NME2	4	NME2 [extracellular region] (R-HSA-6806464) NME2 [secretory granule lumen] (R-HSA-6803277) NME2 [ficolin-1-rich granule lumen] (R-HSA-6803324) NME2 [cytosol] (R-HSA-60024)	0.525	2
UniProt:Q12965 MYO1E			0.524	2
UniProt:Q9UNF0 PACSIN2	1	PACSIN2 [cytosol] (R-HSA-8868267)	0.524	4
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [cytosol] (R-HSA-182957) SH3KBP1 [plasma membrane] (R-HSA-182955) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.524	5
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.524	3
UniProt:O14645 IDLC			0.508	2
UniProt:Q8N157 AHI1	1	AHI1 [cytosol] (R-HSA-6804284)	0.499	2
UniProt:Q96RU3 FNBP1	1	FNBP1 [cytosol] (R-HSA-8862261)	0.499	2
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.488	2
UniProt:Q8NFF5-2 FLAD1			0.488	2
UniProt:P57075-2 UBASH3A			0.488	2
UniProt:P50570 DNM2	5	DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [Golgi membrane] (R-HSA-2980842)	0.488	2
IntAct:EBI-11958528 SH3RF1			0.488	2
UniProt:Q9BUZ4 TRAF4			0.488	2
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.488	2
UniProt:Q96HA8 NTAQ1			0.488	2
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.488	2
UniProt:P54646 PRKAA2	4	p-T172-PRKAA2 [cytosol] (R-HSA-200417) PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.488	2
UniProt:P47897 QARS	2	QARS [mitochondrial matrix] (R-HSA-379592) QARS [cytosol] (R-HSA-379615)	0.488	2
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q15436 SEC23A	4	SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) p-S742,T747 SEC23A [cytosol] (R-HSA-5685740)	0.488	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2