Reactome | Recruitment of ZAP-70 to phosphorylated ITAMs

Recruitment of ZAP-70 to phosphorylated ITAMs

Stable Identifier

R-HSA-202344

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Recruitment of ZAP-70 to phosphorylated ITAMs

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Phosphorylation of the ITAMs by Lck is followed by the recruitment of the ZAP-70 a member of Syk family PTK, to the receptor complex. ZAP-70 is exclusively expressed in T cells and NK cells. The dually phosphorylated ITAMs provide a high-affinity docking site for the tandem SH2-domains of the ZAP-70. Once recruited, ZAP-70 is activated by phosphorylation and will be responsible for the phosphorylation of further downstream molecules. Due to the presence of 10 ITAMs in the TCR complex, up to 10 ZAP-70 molecules may cluster on the fully phosphorylated receptors.

Literature References

PubMed ID	Title	Journal	Year
9850860	The Syk family of protein tyrosine kinases in T-cell activation and development Chu, DH, Morita, CT, Weiss, A	Immunol Rev	1998
8520027	The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes van Oers, NS, Weiss, A	Semin Immunol	1995
12485116	Positive and negative regulation of T-cell activation through kinases and phosphatases Tasken, K, Mustelin, T	Biochem J	2003