Reactome | Phosphorylation of PKC theta

Phosphorylation of PKC theta

Stable Identifier

R-HSA-202222

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Raft localized PKC theta is further phosphorylated and activated by PDK1. The threonine residue (T538) in the kinase domain is the potential target of PDK1. Phosphorylation of this site is critical for the PKC theta kinase activity, and its ability to activate NF-kB pathway. PKC theta is later trans-autophopshorylated on putative phosphorylation sites (S676, S695) for the fine-tuning of its kinase activity.

Literature References

PubMed ID	Title	Journal	Year
16978534	Selective function of PKC-theta in T cells Gupta, S, Manicassamy, S, Sun, Z	Cell Mol Immunol	2006
12473184	Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death Villalba, M, Altman, A	J Biochem (Tokyo)	2002