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WIPF1 [cytosol]
Stable Identifier
R-HSA-201874
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WIP
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43516 WIPF1
Gene Names
WIPF1, WASPIP, WIP
Chain
chain:1-503
Reference Genes
BioGPS Gene:7456 WIPF1
COSMIC (genes):WIPF1 WIPF1
CTD Gene:7456 WIPF1
dbSNP Gene:7456 WIPF1
ENSEMBL:ENSG00000115935 WIPF1
ENSEMBL_homo_sapiens_GENE:ENSG00000115935.19 WIPF1
HGNC:12736 WIPF1
KEGG Gene (Homo sapiens):7456 WIPF1
Monarch:7456 WIPF1
NCBI Gene:7456 WIPF1
OMIM:602357 WIPF1
UCSC:O43516 WIPF1
Reference Transcript
RefSeq:NM_001077269.1 WIPF1
RefSeq:XM_011511780.2 WIPF1
RefSeq:NM_003387.4 WIPF1
Other Identifiers
11718568_a_at
11718569_a_at
11749750_a_at
11749751_s_at
11749752_x_at
11757459_s_at
202663_PM_at
202663_at
202664_PM_at
202664_at
202665_PM_s_at
202665_s_at
2587844
2587845
2587846
2587847
2587848
2587849
2587850
2587851
2587852
2587853
2587854
2587856
2587857
2587858
2587860
2587866
2587867
2587868
2587869
2587871
2587872
2587873
2587878
2587879
2587880
2587883
2587899
2587908
2587924
3452071
35528_at
62743_at
64037_at
7456
8056860
90175_at
A_23_P330611
A_23_P330616
GE60105
GE898404
GO:0001726
GO:0003779
GO:0005515
GO:0005522
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0006457
GO:0007010
GO:0008092
GO:0008154
GO:0015629
GO:0017124
GO:0030029
GO:0030048
GO:0031410
GO:0042995
GO:0043226
GO:0044183
GO:0051707
GO:0065003
HMNXSV003046672
Hs.24143.0.S2_3p_at
Hs.24143.0.S3_3p_at
ILMN_1668417
ILMN_2262957
ILMN_2351298
PH_hs_0024606
TC01000128.hg
TC02002540.hg
TC03000967.hg
TC04001128.hg
TC04001378.hg
TC07001824.hg
TC08000390.hg
TC08000693.hg
TC0X001437.hg
TC10000099.hg
TC12000757.hg
TC14000206.hg
TC14001020.hg
TC15001590.hg
TC19000021.hg
TC19000026.hg
X86019_at
g8400739_3p_a_at
Participates
as a member of
WIP family proteins [cytosol] (Homo sapiens)
Inferred To
Wipf1 [cytosol]
(Mus musculus)
Wipf1 [cytosol]
(Rattus norvegicus)
WIPF1 [cytosol]
(Canis familiaris)
WIPF1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_011510082.1
,
NP_001070737.1
,
NP_003378.3
OpenTargets
ENSG00000115935
HPA
ENSG00000115935-WIPF1
GeneCards
O43516
Ensembl
ENST00000392547
,
ENST00000359761
,
ENSG00000115935
,
ENSP00000513882
,
ENSP00000376330
,
ENST00000272746
,
ENST00000436221
,
ENST00000409891
,
ENST00000392546
,
ENSP00000352802
,
ENST00000698701
,
ENSP00000376329
,
ENST00000698668
,
ENSP00000388454
,
ENSP00000386431
,
ENSP00000503603
,
ENST00000679041
,
ENSP00000513869
,
ENSP00000272746
PRO
O43516
Pharos - Targets
O43516
Orphanet
20821
PDB
2A41
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42768 WAS
2
WAS [cytosol]
(R-HSA-201879)
p-Y291-WAS [cytosol]
(R-HSA-2197668)
0.966
25
UniProt:O00401 WASL
4
N-WASP [cytosol]
(R-HSA-201873)
p-Y256-WASL [cytosol]
(R-HSA-2197672)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.851
8
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.745
4
UniProt:Q60598 Cttn
2
p-S113-Cttn [cytosol]
(R-MMU-442839)
Cttn [cytosol]
(R-MMU-442836)
0.676
4
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.666
4
UniProt:P53992 SEC24C
4
p-SEC24C [cytosol]
(R-HSA-5694551)
SEC24C [ER to Golgi transport vesicle membrane]
(R-HSA-204026)
SEC24C [cytosol]
(R-HSA-203988)
SEC24C [endoplasmic reticulum membrane]
(R-HSA-203987)
0.556
3
UniProt:P13196 ALAS1
2
PXLP-ALAS1 [mitochondrial matrix]
(R-HSA-1022086)
ALAS1 [mitochondrial matrix]
(R-HSA-189438)
0.556
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.463
4
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