Caspase-mediated cleavage of Desmoplakin

Stable Identifier
R-HSA-201636
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cleavage of desmosomal proteins including desmoplakin contributes to cell rounding and disintegration of the intermediate filament system (Weiske et al., 2001). Caspase-3 inhibition prevents desmoplakin cleavage, implicating caspase-3 as the responsible endopeptidase (Weiske et al. 2001).
Literature References
PubMed ID Title Journal Year
11500511 The fate of desmosomal proteins in apoptotic cells

Weiske, J, Tauber, R, Schroder, W, Hatzfeld, M, Schoneberg, T, Huber, O

J Biol Chem 2001
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Orthologous Events
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