Reactome | PARK2 [cytosol]

PARK2 [cytosol]

Stable Identifier

R-HSA-201579

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Parkin

Locations in the PathwayBrowser for interactor UniProt:P41220 RGS2

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External Reference Information

External Reference

UniProt:O60260 PRKN

Gene Names

PARK2, PRKN

Chain

chain:1-465

Reference Genes

BioGPS Gene:5071 PARK2

COSMIC (genes):PARK2 PARK2

CTD Gene:5071 PARK2

dbSNP Gene:5071 PARK2

ENSEMBL:ENSG00000185345 PARK2

HGNC:8607 PARK2

KEGG Gene (Homo sapiens):5071 PARK2

Monarch:5071 PARK2

NCBI Gene:5071 PARK2

OMIM:602544 PARK2

UCSC:O60260 PARK2

Reference Transcript

Other Identifiers

0000110576

0003990500

11740616_a_at

11740617_x_at

11741869_x_at

11741870_a_at

11750453_s_at

11758324_s_at

1555668_a_at

16257

17025440

1IYF

207058_s_at

2983144

2983145

2983146

2983147

2983148

2983149

2983152

2983160

2983209

2983217

2983258

2983288

2983308

2983309

2983321

2983326

2983327

2983351

2983399

2JMO

33019_at

36012

4BM9

4I1F

4I1H

5071

5C1Z

5C23

5C9V

5N2W

5N38

5TR5

6GLC

6HUE

6N13

8130645

86935_r_at

A0A087WU39

A0A087WX46

A0A087X0Z9

A0A087X1E2

A_23_P136077

A_23_P147465

AAH22014

AAM21457

AAM21458

AAM21461

AAS88422

AB009973

ABN46990

ADB90270

ADB90271

ADB91979

AF381282

AF381283

AF381286

AHW56552

AK292590

AL035697

AL132982

AL445215

AP000886

AP000887

AP001576

AP001577

AP001578

AP003699

AY564225

B1AKC3

BAA25751

BAF85279

BC022014

CAB016257

CCDS5281

CCDS5282

CCDS5283

CH471051

EAW47573

EAW47574

EF375726

ENSG00000185345

ENSP00000343589

ENSP00000355860

ENSP00000355862

ENSP00000355863

ENSP00000355865

ENSP00000434414

ENST00000338468

ENST00000338468.7

ENST00000366894

ENST00000366894.5

ENST00000366896

ENST00000366896.5

ENST00000366897

ENST00000366897.5

ENST00000366898

ENST00000366898.5

ENST00000479615

ENST00000479615.5

EntrezGene:5071

EntrezGene:PRKN

g4758883_3p_a_at

GE53239

GO:0000122

GO:0000151

GO:0000209

GO:0000266

GO:0000422

GO:0000423

GO:0000902

GO:0000976

GO:0001227

GO:0001664

GO:0001933

GO:0001963

GO:0001964

GO:0003674

GO:0003677

GO:0003700

GO:0003779

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005783

GO:0005794

GO:0005829

GO:0005975

GO:0006464

GO:0006511

GO:0006513

GO:0006605

GO:0006810

GO:0006914

GO:0006950

GO:0006979

GO:0007005

GO:0007010

GO:0007034

GO:0007165

GO:0007267

GO:0007417

GO:0007612

GO:0007626

GO:0008013

GO:0008092

GO:0008150

GO:0008219

GO:0008270

GO:0008344

GO:0009056

GO:0009058

GO:0010498

GO:0010506

GO:0010628

GO:0010629

GO:0010636

GO:0010637

GO:0010821

GO:0010906

GO:0010994

GO:0014059

GO:0015031

GO:0015631

GO:0016192

GO:0016235

GO:0016236

GO:0016567

GO:0016579

GO:0016607

GO:0016740

GO:0017124

GO:0019538

GO:0019899

GO:0019900

GO:0019901

GO:0022607

GO:0030154

GO:0030165

GO:0030544

GO:0031072

GO:0031396

GO:0031410

GO:0031624

GO:0031625

GO:0031647

GO:0031648

GO:0032092

GO:0032182

GO:0032232

GO:0032368

GO:0032436

GO:0032991

GO:0033132

GO:0034620

GO:0034641

GO:0034976

GO:0035249

GO:0035519

GO:0036503

GO:0040007

GO:0042053

GO:0042415

GO:0042417

GO:0042592

GO:0042802

GO:0042826

GO:0042981

GO:0043005

GO:0043123

GO:0043130

GO:0043161

GO:0043167

GO:0043226

GO:0043274

GO:0043388

GO:0043524

GO:0044257

GO:0044267

GO:0044281

GO:0044314

GO:0044403

GO:0044828

GO:0044877

GO:0045732

GO:0045944

GO:0046329

GO:0046676

GO:0046872

GO:0046928

GO:0048471

GO:0048856

GO:0050804

GO:0050821

GO:0050877

GO:0051087

GO:0051582

GO:0051583

GO:0051865

GO:0051881

GO:0055069

GO:0060548

GO:0060828

GO:0061024

GO:0061630

GO:0061734

GO:0065003

GO:0070050

GO:0070534

GO:0070585

GO:0070842

GO:0070936

GO:0070979

GO:0071287

GO:0085020

GO:0090090

GO:0090141

GO:0090201

GO:0097237

GO:0097413

GO:0097602

GO:0098779

GO:0098793

GO:0099073

GO:0099074

GO:1900407

GO:1901215

GO:1901800

GO:1902236

GO:1902254

GO:1902283

GO:1902530

GO:1902803

GO:1903202

GO:1903214

GO:1903265

GO:1903351

GO:1903377

GO:1903382

GO:1903542

GO:1903599

GO:1903861

GO:1904049

GO:1905281

GO:1905366

GO:1905477

GO:1990381

GO:1990444

GO:1990452

GO:2000377

GO:2000378

GU345839

GU345840

GU361467

HGNC:8607

HPA036012

Hs2.132954.6.S1_3p_s_at

ILMN_1714511

ILMN_2395692

IPR000626

IPR002867

IPR003977

IPR029071

IPR031127

IPR041170

IPR041565

KJ534912

MIM:167000

MIM:211980

MIM:600116

MIM:602544

NM_004562

NM_013987

NM_013988

NP_004553

NP_054642

NP_054643

PARK2

PF00240

PF01485

PF17976

PF17978

PH_hs_0007979

PR01475

PRKN

PRKN-201

PRKN-203

PRKN-204

PRKN-205

PRKN-206

PRKN-207

SM00213

SM00647

TC06002286.hg

UPI00003673FE

UPI00003673FF

UPI0000367400

UPI00004589F1

UPI00004589F2

X5DR79

XM_011535863

XM_017010908

XM_017010909

XM_024446449

XP_011534165

XP_016866397

XP_016866398

XP_024302217

XR_001743443

Participant Of

hasComponent

input

hasCandidate

E3 ligases in proteasomal degradation [cytosol]

Other forms of this molecule

polyUb-PARK2 [cytosol]

Inferred To

Homologues of PARK2 [cytosol] (Dictyostelium discoideum)

Ghost homologue of PARK2 [cytosol] (Caenorhabditis elegans)

Ghost homologue of PARK2 [cytosol] (Rattus norvegicus)

Ghost homologue of PARK2 [cytosol] (Sus scrofa)

Ghost homologue of PARK2 [cytosol] (Xenopus tropicalis)

PARK2 [cytosol] (Bos taurus)

PARK2 [cytosol] (Canis familiaris)

PARK2 [cytosol] (Danio rerio)

PARK2 [cytosol] (Dictyostelium discoideum)

PARK2 [cytosol] (Drosophila melanogaster)

PARK2 [cytosol] (Gallus gallus)

PARK2 [cytosol] (Mus musculus)

PARK2 [cytosol] (Plasmodium falciparum)

PARK2 [cytosol] (Saccharomyces cerevisiae)

PARK2 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_004553.2, NP_054643.2, NP_054642.2

GeneCards

O60260

PRO

O60260

Orphanet

16608

HMDB Protein

HMDBP07955

PDB

5N38, 5C9V, 5C1Z, 5C23, 5N2W, 6HUE, 6GLC, 6N13, 5TR5, 1IYF, 4I1H, 4BM9, 2JMO, 4I1F

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXM7 PINK1	4	PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653)	0.748	7
UniProt:Q15645 PCH2			0.712	4
UniProt:P49792 RANBP2	4	SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) RANBP2 [cytosol] (R-HSA-157703) RANBP2 [nuclear envelope] (R-HSA-2993756)	0.639	11
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.623	10
IntAct:EBI-4399559 UBIQ			0.623	2
UniProt:O60260 PRKN	2	polyUb-PARK2 [cytosol] (R-HSA-5689094) PARK2 [cytosol] (R-HSA-201579)	0.618	5
UniProt:P68510 Ywhah	1	14-3-3 eta [cytosol] (R-MMU-1445091)	0.611	6
UniProt:Q9UBN7 HDAC6	5	HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.602	6
UniProt:Q6NUN9 ZNF746	1	ZNF746 [nucleoplasm] (R-HSA-2586599)	0.591	6
UniProt:Q8IZ52-2 CHPF			0.581	5
UniProt:O95140 MFN2	2	K48polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-5205668) MFN2 [mitochondrial outer membrane] (R-HSA-992714)	0.576	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617)	0.564	2
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:Q9BXM7-1 PINK1			0.544	2
UniProt:Q8IXI2 RHOT1	4	RHOT1 [plasma membrane] (R-HSA-3006728) RHOT1 [cytosol] (R-HSA-3006724) RHOT1 [mitochondrial outer membrane] (R-HSA-5696912) PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139)	0.524	3
UniProt:O14818-1 PSMA7			0.524	5
UniProt:Q16342 PDCD2			0.508	5
UniProt:Q99IB8-PRO_0000045592			0.508	3
UniProt:Q9Z2Q6 SEPT5			0.508	2
UniProt:O35964	1	SH3GL1 [cytosol] (R-RNO-8867732)	0.462	2
UniProt:Q99963-3 SH3GL3			0.462	2
UniProt:O35179 Sh3gl2	5	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-RNO-2130629) SH3GL2 [Golgi membrane] (R-RNO-351189) Endophilin [plasma membrane] (R-RNO-182026) SH3GL2 [plasma membrane] (R-RNO-177495) SH3GL2 [cytosol] (R-RNO-182958)	0.462	2