Reactome | ACTR3 [cytosol]

ACTR3 [cytosol]

Stable Identifier

R-HSA-200811

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ARP3

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHB-mediated forward signaling (Homo sapiens)
        
        N-WASP binds ARP2/3 and G-actin (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Branching and elongation of mother and daughter filaments (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
        
        Actin filament bound Myosin-X [plasma membrane] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Myosin-Actin filaments [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - Branching and elongation of mother and daughter filaments (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
        
        Actin filament bound Myosin-X [plasma membrane] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - Role of myosins in phagosome formation (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Myosin-Actin filaments [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Branching and elongation of mother and daughter filaments (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61158 ACTR3

Gene Names

ACTR3, ARP3

Chain

initiator methionine:, chain:2-418

Reference Genes

BioGPS Gene:10096 ACTR3

COSMIC (genes):ACTR3 ACTR3

CTD Gene:10096 ACTR3

dbSNP Gene:10096 ACTR3

ENSEMBL:ENSG00000115091 ACTR3

ENSEMBL_homo_sapiens_GENE:ENSG00000115091.12 ACTR3

HGNC:170 ACTR3

KEGG Gene (Homo sapiens):10096 ACTR3

Monarch:10096 ACTR3

NCBI Gene:10096 ACTR3

OMIM:604222 ACTR3

UCSC:P61158 ACTR3

Reference Transcript

RefSeq:NM_005721.4 ACTR3

Other Identifiers

10096

11728643_s_at

11751141_a_at

16884797

200996_PM_at

200996_at

213101_PM_s_at

213101_s_at

213102_PM_at

213102_at

228603_PM_at

228603_at

239170_PM_at

239170_at

2501701

2501702

2501703

2501704

2501711

2501714

2501715

2501716

2501717

2501721

2501722

2501728

2501729

2501731

2501733

2501734

2501735

2501736

2501737

2501738

2501739

2501740

2501741

35271_at

47644_at

54274_at

64157_at

69195_at

8044686

A_24_P105771

A_24_P231513

GE58377

GO:0000166

GO:0000910

GO:0002376

GO:0003779

GO:0005198

GO:0005200

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005885

GO:0005903

GO:0005911

GO:0005925

GO:0006351

GO:0006355

GO:0007010

GO:0007018

GO:0007059

GO:0007163

GO:0008092

GO:0008356

GO:0010592

GO:0015629

GO:0016020

GO:0016344

GO:0022414

GO:0030027

GO:0030030

GO:0033206

GO:0034314

GO:0035861

GO:0042995

GO:0043226

GO:0044782

GO:0045944

GO:0048870

GO:0051015

GO:0051321

GO:0051653

GO:0060271

GO:0070062

GO:0070358

GO:0071346

GO:0098542

GO:0140013

HMNXSV003015544

HMNXSV003054012

Hs.10927.1.A1_3p_at

Hs.10927.1.A1_3p_s_at

Hs.195789.0.A1_3p_at

Hs.99410.0.A1_3p_at

ILMN_1657153

PH_hs_0020129

TC02000735.hg

g7262289_3p_at

Participates

as a component of

ACTR3:ATP [cytosol] (Homo sapiens)

Inferred To

Arp3 [cytosol] (Drosophila melanogaster)

act2 [cytosol] (Schizosaccharomyces pombe)

actr3 [cytosol] (Xenopus tropicalis)

ARP3 [cytosol] (Bos taurus)

ARP3 [cytosol] (Saccharomyces cerevisiae)

arx-1 [cytosol] (Caenorhabditis elegans)

arpC [cytosol] (Dictyostelium discoideum)

Actr3 [cytosol] (Mus musculus)

Actr3 [cytosol] (Rattus norvegicus)

ACTR3 [cytosol] (Canis familiaris)

ACTR3 [cytosol] (Danio rerio)

ACTR3 [cytosol] (Gallus gallus)

ACTR3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005712.1

OpenTargets

ENSG00000115091

GeneCards

P61158

HPA

ENSG00000115091-ACTR3

Ensembl

ENST00000263238, ENSP00000263238, ENSG00000115091

PRO

P61158

Pharos - Targets

P61158

PDB

6YW6, 6UHC, 6YW7

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	13
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.556	3

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