ERK1/2 phosphorylates MSK1

Stable Identifier
R-HSA-198756
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MSK1 (Ribosomal protein S6 kinase alpha-5) is a serine/threonine kinase that is localised in the nucleus. It contains two protein kinase domains in a single polypeptide. It can be activated 5-fold by ERK1/2 through phosphorylation at four key residues.
Literature References
PubMed ID Title Journal Year
9687510 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Lucocq, LM, Alessi, DR, Clifton, AD, Deak, M

EMBO J 1998
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!