Reactome | PLOD3 [endoplasmic reticulum membrane]

PLOD3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-1981135

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3, PLOD3_HUMAN, Lysyl hydroxylase 3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60568 PLOD3

Gene Names

PLOD3

Chain

signal peptide:1-24, chain:25-738

Reference Genes

BioGPS Gene:8985 PLOD3

COSMIC (genes):PLOD3 PLOD3

CTD Gene:8985 PLOD3

dbSNP Gene:8985 PLOD3

ENSEMBL:ENSG00000106397 PLOD3

ENSEMBL_homo_sapiens_GENE:ENSG00000106397.12 PLOD3

HGNC:9083 PLOD3

KEGG Gene (Homo sapiens):8985 PLOD3

Monarch:8985 PLOD3

NCBI Gene:8985 PLOD3

OMIM:603066 PLOD3

UCSC:O60568 PLOD3

Reference Transcript

RefSeq:NM_001084.4 PLOD3

Other Identifiers

11715786_at

11747563_a_at

11749505_a_at

11749506_x_at

11758519_s_at

17060857

202185_PM_at

202185_at

3064542

3064543

3064545

3064549

3064551

3064552

3064554

3064556

3064558

3064559

3064560

3064561

3064562

3064563

3064565

3064567

3064569

3064570

3064571

3064572

3064573

39801_at

8141688

8985

A_23_P168788

GE54960

GO:0001701

GO:0001886

GO:0003013

GO:0003824

GO:0005506

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005789

GO:0005791

GO:0005794

GO:0005802

GO:0006486

GO:0006493

GO:0006520

GO:0006575

GO:0008104

GO:0008152

GO:0008475

GO:0016020

GO:0016491

GO:0016705

GO:0016740

GO:0016757

GO:0017185

GO:0021915

GO:0030154

GO:0030198

GO:0030199

GO:0030312

GO:0031012

GO:0031418

GO:0032963

GO:0033823

GO:0036094

GO:0036211

GO:0042311

GO:0043226

GO:0046872

GO:0046947

GO:0048730

GO:0048856

GO:0050211

GO:0051213

GO:0060425

GO:0062023

GO:0070062

GO:0070831

GO:0140096

GO:1901135

HMNXSV003054741

ILMN_1774836

PH_hs_0009226

TC07001687.hg

g4505890_3p_at

Participates

as a component of

PLOD3:Fe2+ dimer [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

cb479 [endoplasmic reticulum membrane] (Danio rerio)

plod3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

PLOD3 [endoplasmic reticulum membrane] (Bos taurus)

PLOD3 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

PLOD3 [endoplasmic reticulum membrane] (Canis familiaris)

PLOD3 [endoplasmic reticulum membrane] (Drosophila melanogaster)

PLOD3 [endoplasmic reticulum membrane] (Mus musculus)

PLOD3 [endoplasmic reticulum membrane] (Rattus norvegicus)

PLOD3 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001075.1

OpenTargets

ENSG00000106397

IntEnz

2.4.1.66, 1.14.11.4

HPA

ENSG00000106397-PLOD3

GeneCards

O60568

Ensembl

ENST00000223127, ENSG00000106397, ENSP00000223127

PRO

O60568

Pharos - Targets

O60568

Orphanet

21187

HMDB Protein

HMDBP00462

PDB

6WFV, 6FXK, 6FXX, 6TES, 6TEZ, 6FXY, 6FXR, 6TEX, 6TEC, 6FXT, 8ONE, 6TEU, 6FXM, 6TE3

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.831	8
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.666	4
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q9UHH9 IP6K2	1	IP6K2 [nucleoplasm] (R-HSA-1015687)	0.556	3
UniProt:Q9UMD9 COL17A1	20	GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173102) GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173084) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173190) 3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173237) 3x4Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173184) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173264) 3x4Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172934) 3x4Hyp-3Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172989) 3x4Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173162) 3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173230) 5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173044) 3x4Hyp-GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471866) 5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471851) 3x4Hyp-3Hyp-COL17A1(?-1497) [extracellular region] (R-HSA-2471867) 3x4Hyp-5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471913) 3x4Hyp-3Hyp-5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471897) COL17A1(?-1497) [extracellular region] (R-HSA-2471870) GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471903) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471916) 3x4Hyp-COL17A1(?-1497) [extracellular region] (R-HSA-2471874)	0.556	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	2