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ITGB2 [plasma membrane]
Stable Identifier
R-HSA-198010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin beta-2, ITB2_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
LFA-1:ICAM 1-5 [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2:F11R [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2:JAM3 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2 binds JAM3 (Homo sapiens)
Integrin alphaXbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2:JAM3 [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)
Integrin alphaDbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Homo sapiens)
Integrin alphaDbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Interaction of integrin alphaXbeta2 with fibrin (Homo sapiens)
Integrin alphaXbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2:fibrin multimer [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2:F11R [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2:JAM3 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2 binds JAM3 (Homo sapiens)
Integrin alphaXbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2:JAM3 [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
LFA-1:ICAM 1-5 [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)
IL13-upregulated proteins [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
CD14:LPS binds CR3 (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
LPS:CD14:CR3 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGB2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05107 ITGB2
Gene Names
ITGB2, CD18, MFI7
Chain
signal peptide:1-22, chain:23-769
Reference Genes
BioGPS Gene:3689 ITGB2
COSMIC (genes):ITGB2 ITGB2
CTD Gene:3689 ITGB2
dbSNP Gene:3689 ITGB2
ENSEMBL:ENSG00000160255 ITGB2
ENSEMBL_homo_sapiens_GENE:ENSG00000160255.19 ITGB2
HGNC:6155 ITGB2
KEGG Gene (Homo sapiens):3689 ITGB2
Monarch:3689 ITGB2
NCBI Gene:3689 ITGB2
OMIM:600065 ITGB2
UCSC:P05107 ITGB2
Reference Transcript
RefSeq:NM_000211.4 ITGB2
RefSeq:NM_001303238.1 ITGB2
RefSeq:NM_001127491.2 ITGB2
Other Identifiers
11717337_a_at
1555349_PM_a_at
1555349_a_at
202803_PM_s_at
202803_s_at
3689
37918_at
3934731
3934732
3934734
3934736
3934738
3934739
3934740
3934741
3934743
3934744
3934746
3934753
3934755
3934756
3934757
3934758
3934760
3934763
3934764
3934769
3934772
3934773
3934774
3934775
3934776
3934777
58602_at
8070826
A_23_P329573
GO:0001540
GO:0001774
GO:0001851
GO:0002376
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005925
GO:0006886
GO:0006898
GO:0006909
GO:0006911
GO:0006915
GO:0006954
GO:0007155
GO:0007159
GO:0007160
GO:0007229
GO:0007267
GO:0008305
GO:0008360
GO:0009897
GO:0009986
GO:0012501
GO:0016020
GO:0016192
GO:0019901
GO:0023052
GO:0030154
GO:0030369
GO:0030593
GO:0031072
GO:0031410
GO:0031623
GO:0032930
GO:0034113
GO:0034687
GO:0034688
GO:0034689
GO:0035579
GO:0035987
GO:0036211
GO:0038024
GO:0043113
GO:0043226
GO:0043235
GO:0043315
GO:0044853
GO:0045121
GO:0045963
GO:0046872
GO:0048856
GO:0048870
GO:0050730
GO:0050839
GO:0060089
GO:0061024
GO:0070062
GO:0070821
GO:0071404
GO:0090314
GO:0097242
GO:0098609
GO:0098742
GO:0101003
GO:1903561
GO:1904996
GO:1990266
GO:2000363
HMNXSV003010714
Hs.323138.0.A1_3p_s_at
Hs2.83968.2.S1_3p_s_at
ILMN_2175912
M15395_at
PH_hs_0018273
X64072_s_at
Participates
as a member of
IL13-upregulated proteins [plasma membrane] (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
as a component of
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
Integrin alphaXbeta2 [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
Integrin alphaDbeta2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
ITGB2 [ficolin-1-rich granule membrane]
ITGB2 [specific granule membrane]
ITGB2 [tertiary granule membrane]
Inferred To
Itgb2 [plasma membrane]
(Rattus norvegicus)
pat-3 [plasma membrane]
(Caenorhabditis elegans)
ITGB2 [plasma membrane]
(Bos taurus)
ITGB2 [plasma membrane]
(Caenorhabditis elegans)
ITGB2 [plasma membrane]
(Canis familiaris)
ITGB2 [plasma membrane]
(Gallus gallus)
ITGB2 [plasma membrane]
(Mus musculus)
ITGB2 [plasma membrane]
(Sus scrofa)
mys [plasma membrane]
(Drosophila melanogaster)
Homologues of ITGB2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ITGB2 [plasma membrane]
(Drosophila melanogaster)
Itgbn [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001290167.1
,
NP_000202.3
,
NP_001120963.2
Guide to Pharmacology - Targets
2456
OpenTargets
ENSG00000160255
GeneCards
P05107
HPA
ENSG00000160255-ITGB2
Ensembl
ENSG00000160255
,
ENSP00000347279
,
ENSP00000380955
,
ENST00000397857
,
ENST00000397852
,
ENST00000355153
,
ENSP00000380948
,
ENST00000302347
,
ENST00000397850
,
ENSP00000380950
,
ENSP00000303242
PRO
P05107
Pharos - Targets
P05107
Orphanet
16273
HMDB Protein
HMDBP02085
PDB
5E6S
,
2P26
,
5ES4
,
2V7D
,
4NEH
,
5ZAZ
,
5XR1
,
5E6X
,
5E6R
,
5E6W
,
2JF1
,
7P2D
,
3K72
,
1YUK
,
7USM
,
5E6V
,
4NEN
,
3K6S
,
5E6U
,
7USL
,
3K71
,
2P28
,
1L3Y
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96S59 RANBP9
1
RANBP9 [cytosol]
(R-HSA-374586)
0.611
4
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P00519 ABL1
5
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
0.524
4
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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