Reactome | p75NTR binds to NADE

p75NTR binds to NADE

Stable Identifier

R-HSA-193650

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The NADE protein interacts with p75NTR to mediate cell death. The interaction is mediated by NADE NES (nuclear export signal), also responsible for self-association of NADE (Mukai J et al, 2002).

Literature References

PubMed ID	Title	Journal	Year
10764727	NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR Irie, S, Shoji-Hoshino, S, Li, Y, Hanaoka, T, Greene, LA, Suvanto, P, Kimura, MT, Mukai, J, Hachiya, T, Sato, TA, Nadano, D	J Biol Chem	2000