Binding of M1 to vRNP

Stable Identifier
R-HSA-192746
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
5/5
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Binding of M1 to vRNP
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M1 protein binds to viral RNP through its C-terminal domain (Baudin, 2001). The influenza M1 protein accumulates in the infected cell nucleus through a nuclear localization signal (NLS) RKLKR (residues 101-105) in its N-terminus (Ye, 1999). A host cell protein, HSP70, is thought to inhibit M1 binding at nonpermissive temperatures (Hirayama et al., 2004).
Literature References
PubMed ID Title Journal Year
11222100 In vitro dissection of the membrane and RNP binding activities of influenza virus M1 protein

Petit, I, Weissenhorn, W, Baudin, F, Ruigrok, RW

Virology 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HSPA1A [nucleoplasm] (Homo sapiens)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Garcia-Sastre, A  (2007-02-13)
Bortz, E  (2007-02-13)
Reviewed
Squires, B  (2007-02-13)
Created
Gillespie, ME  (2007-02-07)
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