Reactome | Mevalonate-5-phosphate is further phosphorylated

Mevalonate-5-phosphate is further phosphorylated

Stable Identifier

R-HSA-191422

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(R)-5-phosphomevalonate + ATP => (R)-5-diphosphomevalonate + ADP

ReviewStatus

5/5

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Mevalonate-5-phosphate is further phosphorylated

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Cytosolic phosphomevalonate kinase (PMK) catalyzes the reversible, ATP-dependent phosphorylation of mevalonate-5-phosphate (MVA5P), producing mevalonate-5-pyrophosphate (MVA5PP) (Herdendorf & Miziorko 2006; Hogenboom et al. 2004; ).

Literature References

PubMed ID	Title	Journal	Year
14729858	Phosphomevalonate kinase is a cytosolic protein in humans Hogenboom, S, Tuyp, JJ, Espeel, M, Koster, J, Wanders, RJA, Waterham, HR	J Lipid Res	2004
16519518	Phosphomevalonate kinase: functional investigation of the recombinant human enzyme Herdendorf, TJ, Miziorko, HM	Biochemistry	2006