Association of Cyclin A:Cdk2 with Cdh1

Stable Identifier
R-HSA-188371
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Association of Cyclin A:Cdk2 with Cdh1
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Cyclin A-Cdk2 prevents unscheduled APC reactivation during S phase by binding and subsequently phosphorylating Cdh1. Phosphorylation-dependent dissociation of the Cdh1-activating subunit inhibits the APC/C.
Literature References
PubMed ID Title Journal Year
11340163 A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression

Lukas, J, Peters, JM, Kramer, ER, Sorensen, CS, Lukas, C

Mol Cell Biol 2001
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Output
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Orthologous Events
Association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)
Association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)
Association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)
Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)
Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
Association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)
Association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)
Association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)
Authored
Lorca, T  (2006-10-10)
Castro, A  (2006-10-10)
Reviewed
Peters, JM  (2006-10-10)
Created
Matthews, L  (2006-10-10)
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