Reactome | Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2

Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2

Stable Identifier

R-HSA-187948

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2

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Active Cyclin A:Cdk2 complexes phosphorylate and inactivate proteins required for maintaining the G1/S phase including. In addition to CDKN1A and CDKN1B, the active CCNA:p-T160-CDK2 complex also phosphorylates FZR1 (Cdh1) and RB1. All this creates auto-amplification loops that render Cdk2 increasingly more active. In G2, Cdk2, in association with cyclin A, phosphorylates E2F1 and E2F3 resulting in the inactivation and possibly degradation of these two transcription factors (Dynlacht et al., 1994; Krek et al., 1994).

Literature References

PubMed ID	Title	Journal	Year
12730199	Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase Hershko, A, Bornstein, G, Pagano, M, Bloom, J, Nakayama, K, Sitry-Shevah, D	J Biol Chem	2003
10323868	Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation Eytan, E, Draetta, GF, Hershko, A, Montagnoli, A, Pagano, M, Carrano, AC, Fiore, F	Genes Dev	1999
16582612	Dual regulation of the anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexes Lengel, KL, Enders, GH, Mitra, J, Azizkhan-Clifford, J	Cell Cycle	2006
10375532	p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 Sun, H, Zhang, H, Tsvetkov, LM, Lee, SJ, Yeh, KH	Curr Biol	1999