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Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
Stable Identifier
R-HSA-187926
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Participants
components
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
Participant Of
input
Cyclin A:Cdk2 mediated phosphorylation of p27/p21
output
Inactivation of Cyclin A:Cdk2 complexes by p27/p21
This entity regulates
Negatively
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1
Inferred To
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Canis familiaris)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Danio rerio)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Gallus gallus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Rattus norvegicus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Sus scrofa)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Xenopus tropicalis)
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