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PIP5K1A [cytosol]
Stable Identifier
R-HSA-1806260
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha, PI51A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Homo sapiens)
PIP5K1A/B [cytosol] (Homo sapiens)
PIP5K1A [cytosol] (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1A [cytosol] (Homo sapiens)
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP5K1A [cytosol] (Homo sapiens)
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Homo sapiens)
PIP5K1A/B [cytosol] (Homo sapiens)
PIP5K1A [cytosol] (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99755 PIP5K1A
Gene Names
PIP5K1A
Chain
chain:1-562
Reference Genes
BioGPS Gene:8394 PIP5K1A
COSMIC (genes):PIP5K1A PIP5K1A
CTD Gene:8394 PIP5K1A
dbSNP Gene:8394 PIP5K1A
ENSEMBL:ENSG00000143398 PIP5K1A
ENSEMBL_homo_sapiens_GENE:ENSG00000143398.20 PIP5K1A
HGNC:8994 PIP5K1A
KEGG Gene (Homo sapiens):8394 PIP5K1A
Monarch:8394 PIP5K1A
NCBI Gene:8394 PIP5K1A
OMIM:603275 PIP5K1A
UCSC:Q99755 PIP5K1A
Reference Transcript
RefSeq:NM_001135637.1 PIP5K1A
RefSeq:NM_001135638.1 PIP5K1A
RefSeq:NM_001135636.1 PIP5K1A
RefSeq:NM_003557.2 PIP5K1A
RefSeq:NM_001330689.1 PIP5K1A
Other Identifiers
11718889_x_at
11728550_x_at
11741025_a_at
11741026_x_at
11741726_s_at
11750217_a_at
207391_3p_s_at
207391_PM_s_at
207391_s_at
210256_PM_s_at
210256_s_at
211205_PM_x_at
211205_x_at
2358762
2358763
2358764
2358765
2358778
2358779
2358781
2358783
2358784
2358785
2358789
2358790
2358792
2358794
2358795
2358797
2358798
2358799
2358800
2358804
2358807
2358808
2358809
2358810
2358811
2358812
2358813
2894038
2894039
2894040
31833_at
3300879
3300880
3300881
3300882
3300884
3300885
7905365
8394
88218_at
A_23_P23572
A_23_P368205
GE59429
GO:0000166
GO:0000285
GO:0001726
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005847
GO:0005886
GO:0005925
GO:0006629
GO:0006650
GO:0006661
GO:0006909
GO:0007010
GO:0007155
GO:0007165
GO:0008654
GO:0010761
GO:0016020
GO:0016192
GO:0016301
GO:0016307
GO:0016308
GO:0016310
GO:0016477
GO:0016607
GO:0016740
GO:0019900
GO:0023052
GO:0030027
GO:0030036
GO:0030154
GO:0030216
GO:0032587
GO:0034330
GO:0042995
GO:0043226
GO:0046488
GO:0046854
GO:0048041
GO:0048856
GO:0048870
GO:0051896
GO:0052742
GO:0052810
GO:0060326
GO:0072659
GO:0090630
GO:0097178
HMNXSV003047286
ILMN_1769869
ILMN_1818232
PH_hs_0031845
PH_hs_0035303
TC01001204.hg
TC01004740.hg
U78575_at
g1743872_3p_a_at
g4505814_3p_a_at
Participates
as a member of
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP5K1A/B [cytosol] (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
Inferred To
pip5k1a [cytosol]
(Danio rerio)
sktl [cytosol]
(Drosophila melanogaster)
PIPkinA [cytosol]
(Dictyostelium discoideum)
MSS4 [cytosol]
(Saccharomyces cerevisiae)
PIP5K59B [cytosol]
(Drosophila melanogaster)
its3 [cytosol]
(Schizosaccharomyces pombe)
Homologues of PIP5K1A [cytosol]
(Dictyostelium discoideum)
Homologues of PIP5K1A [cytosol]
(Drosophila melanogaster)
PIP5K1A [cytosol]
(Bos taurus)
PIP5K1A [cytosol]
(Canis familiaris)
PIP5K1A [cytosol]
(Dictyostelium discoideum)
PIP5K1A [cytosol]
(Gallus gallus)
PIP5K1A [cytosol]
(Plasmodium falciparum)
PIP5K1A [cytosol]
(Sus scrofa)
Pip5k1a [cytosol]
(Mus musculus)
Pip5k1a [cytosol]
(Rattus norvegicus)
ppk-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001129108.1
,
NP_001129109.1
,
NP_003548.1
,
NP_001317618.1
,
NP_001129110.1
ZINC - World Drugs
PI51A_HUMAN
Guide to Pharmacology - Targets
2164
OpenTargets
ENSG00000143398
ZINC - FDA approved
PI51A_HUMAN
ZINC - Substances
PI51A_HUMAN
ZINC - Biogenic
PI51A_HUMAN
ZINC target
Q99755
PRO
Q99755
ZINC - Investigational
PI51A_HUMAN
HPA
ENSG00000143398-PIP5K1A
GeneCards
Q99755
Ensembl
ENSG00000143398
,
ENST00000349792
,
ENSP00000357883
,
ENSP00000271663
,
ENST00000368890
,
ENSP00000357885
,
ENST00000441902
,
ENSP00000415648
,
ENST00000368888
Pharos - Targets
Q99755
ZINC - Predictions - Purchasable
PI51A_HUMAN
HMDB Protein
HMDBP12104
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01116 KRAS
20
S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674814)
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674821)
KRAS A146T [plasma membrane]
(R-HSA-9649623)
KRAS K147E [plasma membrane]
(R-HSA-9651169)
KRAS K147T [plasma membrane]
(R-HSA-9651180)
KRAS V14G [plasma membrane]
(R-HSA-9651295)
KRAS K147N [plasma membrane]
(R-HSA-9651177)
KRAS A146V [plasma membrane]
(R-HSA-9649626)
KRAS A146S [plasma membrane]
(R-HSA-9649621)
KRAS A146P [plasma membrane]
(R-HSA-9649617)
KRAS P34R [plasma membrane]
(R-HSA-9651276)
KRAS P34L [plasma membrane]
(R-HSA-9651269)
KRAS G12A [plasma membrane]
(R-HSA-9649088)
KRAS G12R [plasma membrane]
(R-HSA-9649090)
KRAS G13V [plasma membrane]
(R-HSA-9649644)
KRAS G13S [plasma membrane]
(R-HSA-9649642)
KRAS G13C [plasma membrane]
(R-HSA-9649636)
KRAS G13R [plasma membrane]
(R-HSA-9649639)
KRAS G13A [plasma membrane]
(R-HSA-9649632)
KRAS K5N [plasma membrane]
(R-HSA-9651361)
0.661
9
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