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CD4 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-180575
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Vpu mediated degradation of CD4 (Homo sapiens)
Association of Vpu with CD4 (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
Degradation of ubiquitinated CD4 (Homo sapiens)
multiubiquitinated CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
The Vpu:CD4:beta-TrCP complex recruits SKP1 (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex (Homo sapiens)
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
multiubiquitinated CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
Vpu:CD4 associates with beta-TrCP (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01730 CD4
Gene Names
CD4
Chain
signal peptide:1-25, chain:26-458
Reference Genes
BioGPS Gene:920 CD4
COSMIC (genes):CD4 CD4
CTD Gene:920 CD4
dbSNP Gene:920 CD4
ENSEMBL:ENSG00000010610 CD4
HGNC:1678 CD4
KEGG Gene (Homo sapiens):920 CD4
Monarch:920 CD4
NCBI Gene:920 CD4
OMIM:186940 CD4
UCSC:P01730 CD4
Reference Transcript
RefSeq:NM_000616.4 CD4
Other Identifiers
0002320156
11
1146_at
11738979_x_at
11738980_a_at
11738981_x_at
11738982_at
11750157_at
16747417
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
203547_at
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3402787
3402788
3402790
3402791
3402793
3402798
3402800
3402801
3402802
3402803
3402804
3402807
3402810
3402811
3402812
3402813
3402815
35517_at
3B71
3CD4
3J70
3JCB
3JCC
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4252
4472
48538_at
4H8W
4JM2
4P9H
4Q6I
4R2G
4R4H
4RQS
5A7X
5A8H
5CAY
5THR
5U1F
5VN3
68180
6CM3
6EDU
6MEO
6MET
7953428
920
A_14_P100337
A_24_P295999
AAA16069
AAA35572
AAB51309
AAH25782
AAV38594
AAV38614
AAY22175
AK312828
BAG35684
BC025782
BT019791
BT019811
CAB000011
CAB068180
CCDS8562
CD4
CD4-201
CH471116
DQ012936
EAW88738
EAW88739
ENSG00000010610
ENSP00000011653
ENST00000011653
ENST00000011653.8
EntrezGene:920
EntrezGene:CD4
F5GYA9
F5H480
GE61155
GO:0001618
GO:0001816
GO:0001934
GO:0002250
GO:0002376
GO:0003674
GO:0004888
GO:0005102
GO:0005198
GO:0005201
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005768
GO:0005769
GO:0005783
GO:0005788
GO:0005789
GO:0005886
GO:0005887
GO:0006464
GO:0006810
GO:0006948
GO:0006950
GO:0006955
GO:0007155
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0008150
GO:0008270
GO:0008283
GO:0009058
GO:0009897
GO:0009986
GO:0010524
GO:0015026
GO:0016020
GO:0016021
GO:0016032
GO:0019064
GO:0019221
GO:0019865
GO:0019899
GO:0019901
GO:0030154
GO:0030217
GO:0030225
GO:0030260
GO:0030665
GO:0031410
GO:0032355
GO:0032507
GO:0032991
GO:0033280
GO:0033674
GO:0034641
GO:0035397
GO:0035723
GO:0038023
GO:0042011
GO:0042012
GO:0042101
GO:0042102
GO:0042110
GO:0042289
GO:0042592
GO:0042802
GO:0042803
GO:0043123
GO:0043167
GO:0043226
GO:0043410
GO:0044403
GO:0045058
GO:0045086
GO:0045121
GO:0045657
GO:0045860
GO:0045893
GO:0046598
GO:0048856
GO:0050690
GO:0050731
GO:0050829
GO:0050850
GO:0050852
GO:0050863
GO:0050870
GO:0051924
GO:0061024
GO:0070374
GO:0097011
GO:1990782
HGNC:1678
HPA004252
HPA004472
Hs.17483.0.S2_3p_at
ILMN_1727284
IPR000973
IPR003598
IPR003599
IPR007110
IPR008424
IPR013106
IPR013151
IPR013783
IPR015274
IPR021963
IPR036179
M12807
M35160
MIM:186940
MIM:613949
NM_000616
NM_001195014
NM_001195015
NM_001195016
NM_001195017
NP_000607
NP_001181943
NP_001181944
NP_001181945
NP_001181946
PF00047
PF05790
PF09191
PF12104
PH_hs_0001579
PR00692
SM00406
SM00408
SM00409
TC12000092.hg
TC12002205.hg
U47924
UPI0000001294
XM_017020228
XP_016875717
Participant Of
input
Association of Vpu with CD4
hasComponent
CD4:Vpu complex [endoplasmic reticulum membrane]
Other forms of this molecule
CD4 [clathrin-coated endocytic vesicle membrane]
CD4 [early endosome]
CD4 [plasma membrane]
Cross References
RefSeq
NP_000607.1
OpenTargets
ENSG00000010610
GeneCards
P01730
ZINC - Substances
CD4_HUMAN
ZINC target
P01730
PRO
P01730
ZINC - Predictions - Purchasable
CD4_HUMAN
PDB
1CDI
,
2NY3
,
1CDJ
,
5VN3
,
2NY4
,
6EDU
,
2QAD
,
2NY5
,
1Q68
,
2NY6
,
4R2G
,
1CDU
,
3S4S
,
1CDY
,
2KLU
,
4JM2
,
1WBR
,
6MET
,
3CD4
,
1OPN
,
6MEO
,
3S5L
,
5CAY
,
2JKR
,
1RZJ
,
4H8W
,
5U1F
,
1OPT
,
2JKT
,
3LQA
,
1G9M
,
1OPW
,
3O2D
,
1RZK
,
2B4C
,
1G9N
,
1WIP
,
3B71
,
1WIO
,
1JL4
,
5THR
,
4Q6I
,
3J70
,
3T0E
,
5A7X
,
1WIQ
,
2NY0
,
4P9H
,
4R4H
,
2NXY
,
3JCB
,
2NXZ
,
1GC1
,
3JWD
,
5A8H
,
3JWO
,
2NY1
,
2NY2
,
6CM3
,
4RQS
,
1CDH
,
3JCC
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06239 LCK
4
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
LCK [cytosol]
(R-HSA-167609)
p-Y394-LCK [cytosol]
(R-HSA-202308)
0.702
3
UniProt:P04578-PRO_0000038427 ENV
0.618
3
UniProt:Q2N0S6 Q2N0S6
0.618
3
UniProt:P51681 CCR5
1
CCR5 [plasma membrane]
(R-HSA-171279)
0.564
2
UniProt:P01730 CD4
4
CD4 [early endosome]
(R-HSA-182147)
CD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869082)
CD4 [endoplasmic reticulum membrane]
(R-HSA-180575)
CD4 [plasma membrane]
(R-HSA-167542)
0.558
2
UniProt:P03407 NEF
0.558
2
UniProt:Q1PHM6 Q1PHM6
0.558
2
UniProt:P04578 env
7
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
ENV [viral envelope]
(R-HIV-173439)
0.558
2
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.524
3
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