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CDK5 [cytosol]
Stable Identifier
R-HSA-180064
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser for interactor UniProt:Q5MJ70 SPDYA
Expand all
Disease (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5 binds p25 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Cables link CDK5 and ABL1 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00535 CDK5
Gene Names
CDK5, CDKN5
Chain
chain:1-292
Reference Genes
BioGPS Gene:1020 CDK5
COSMIC (genes):CDK5 CDK5
CTD Gene:1020 CDK5
dbSNP Gene:1020 CDK5
ENSEMBL:ENSG00000164885 CDK5
HGNC:1774 CDK5
KEGG Gene (Homo sapiens):1020 CDK5
Monarch:1020 CDK5
NCBI Gene:1020 CDK5
OMIM:123831 CDK5
UCSC:Q00535 CDK5
Reference Transcript
RefSeq:NM_004935.3 CDK5
RefSeq:NM_001164410.2 CDK5
Other Identifiers
0005860309
1020
11751815_a_at
11754938_a_at
1206_at
17064360
1H4L
1LFR
1UNG
1UNH
1UNL
204247_s_at
3079314
3079315
3079316
3079317
3079319
3079320
3079321
3079322
3079323
3079324
3079325
3079326
3079328
3079329
3079330
3113884
3O0G
40549_at
4AU8
64535
8143850
8909
A0A090N7W4
A0A0S2Z355
A_23_P8400
AACC02000108
AAH05115
AAL15435
AAP35326
ABD66016
AC010973
ADO22451
ALQ33426
ALQ33427
AY049778
BC005115
BT006680
CAA47007
CAB008909
CCDS47748
CCDS55184
CDK5
CDK5-201
CDK5-204
CH471173
DQ411039
EAL24498
EAW54049
ENSG00000164885
ENSP00000297518
ENSP00000419782
ENST00000297518
ENST00000297518.4
ENST00000485972
ENST00000485972.5
EntrezGene:1020
EntrezGene:CDK5
g4826674_3p_at
GE57557
GE86263
GO:0000166
GO:0000226
GO:0000902
GO:0001764
GO:0001934
GO:0001963
GO:0002039
GO:0003674
GO:0004672
GO:0004674
GO:0004693
GO:0005176
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0006464
GO:0006468
GO:0006605
GO:0006810
GO:0006886
GO:0006887
GO:0006913
GO:0006914
GO:0006915
GO:0006950
GO:0007005
GO:0007010
GO:0007049
GO:0007155
GO:0007160
GO:0007165
GO:0007267
GO:0007268
GO:0007399
GO:0007409
GO:0007416
GO:0007519
GO:0008045
GO:0008092
GO:0008150
GO:0008219
GO:0008306
GO:0008542
GO:0009056
GO:0009058
GO:0009611
GO:0014044
GO:0014069
GO:0015031
GO:0016020
GO:0016079
GO:0016192
GO:0016241
GO:0016301
GO:0016310
GO:0016477
GO:0016533
GO:0016572
GO:0016740
GO:0018105
GO:0018107
GO:0019233
GO:0019899
GO:0019901
GO:0021537
GO:0021549
GO:0021695
GO:0021697
GO:0021766
GO:0021819
GO:0021954
GO:0021987
GO:0022038
GO:0022607
GO:0022857
GO:0030027
GO:0030054
GO:0030154
GO:0030175
GO:0030182
GO:0030334
GO:0030424
GO:0030425
GO:0030426
GO:0030517
GO:0030549
GO:0030866
GO:0030900
GO:0031175
GO:0031397
GO:0031594
GO:0031914
GO:0032092
GO:0032801
GO:0032991
GO:0034352
GO:0034641
GO:0035249
GO:0035418
GO:0040007
GO:0040011
GO:0042220
GO:0042501
GO:0042592
GO:0042981
GO:0042995
GO:0043005
GO:0043025
GO:0043113
GO:0043125
GO:0043167
GO:0043204
GO:0043226
GO:0043525
GO:0045055
GO:0045202
GO:0045211
GO:0045786
GO:0045860
GO:0045861
GO:0045892
GO:0045956
GO:0046777
GO:0046826
GO:0046875
GO:0048148
GO:0048156
GO:0048167
GO:0048488
GO:0048489
GO:0048511
GO:0048646
GO:0048675
GO:0048709
GO:0048812
GO:0048813
GO:0048856
GO:0048870
GO:0050321
GO:0050877
GO:0051276
GO:0051301
GO:0051402
GO:0051879
GO:0051966
GO:0055085
GO:0060078
GO:0060079
GO:0061001
GO:0070509
GO:0071156
GO:0090314
GO:0098685
GO:0098793
GO:0098794
GO:0098883
GO:0098978
GO:0099533
GO:0099601
GO:0099635
GO:0099703
GO:1901215
GO:1901216
GO:1901387
GO:1901796
GO:1903076
GO:1903421
GO:1904646
GO:2000251
GQ900934
HGNC:1774
HPA064535
ILMN_1754375
ILMN_1781987
IPR000719
IPR008271
IPR011009
IPR017441
KU177968
KU177969
MIM:123831
MIM:616342
NM_001164410
NM_004935
NP_001157882
NP_004926
PF00069
PH_hs_0029292
PH_hs_0031953
SM00220
TC07002027.hg
UPI0000113588
UPI0000ECE480
X66364
X66364_at
Participant Of
hasComponent
CDK5:CABLES:ABL [cytosol]
CDK5:p25 [cytosol]
CDK5:p35 [plasma membrane]
input
Cables link CDK5 and ABL1
CDK5 binds p25
Ntrk2 phosohorylates CDK5
Other forms of this molecule
p-Y15-CDK5 [cytosol]
p-Y15,S159-CDK5 [nucleoplasm]
CDK5 [nucleoplasm]
Inferred To
Cdk5 [cytosol] (Mus musculus)
Cdk5 [cytosol] (Rattus norvegicus)
CDK5 [cytosol] (Bos taurus)
CDK5 [cytosol] (Canis familiaris)
CDK5 [cytosol] (Danio rerio)
CDK5 [cytosol] (Gallus gallus)
CDK5 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001157882.1
,
NP_004926.1
ZINC - World Drugs
CDK5_HUMAN
OpenTargets
ENSG00000164885
ZINC - FDA approved
CDK5_HUMAN
ZINC - Substances
CDK5_HUMAN
ZINC - Biogenic
CDK5_HUMAN
ZINC target
Q00535
PRO
Q00535
PDB
1UNH
,
1UNG
,
1H4L
,
1LFR
,
3O0G
,
1UNL
,
4AU8
ZINC - Investigational
CDK5_HUMAN
ZINC - Metabolites
CDK5_HUMAN
GeneCards
Q00535
Orphanet
26306
ZINC - Predictions - Purchasable
CDK5_HUMAN
HMDB Protein
HMDBP01398
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30279 CCND2
2
CCND2 [nucleoplasm]
(R-HSA-113827)
CCND2 [cytosol]
(R-HSA-68340)
0.949
14
UniProt:Q15078 CDK5R1
4
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
0.905
12
UniProt:P46527 CDKN1B
8
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.875
8
UniProt:Q8TDN4 CABLES1
2
CABLES1 [nucleoplasm]
(R-HSA-1013870)
CABLES1 [cytosol]
(R-HSA-1013859)
0.802
6
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.793
5
UniProt:P30281 CCND3
2
CCND3 [nucleoplasm]
(R-HSA-113835)
CCND3 [cytosol]
(R-HSA-68333)
0.775
5
UniProt:Q86YS7 C2CD5
2
p-S197-C2CD5 [plasma membrane]
(R-HSA-5260194)
C2CD5 [plasma membrane]
(R-HSA-5216175)
0.725
4
UniProt:P14635 CCNB1
4
CCNB1 [cytosol]
(R-HSA-157451)
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
0.725
4
UniProt:Q00526 CDK3
0.643
3
UniProt:Q9BTV7 CABLES2
1
CABLES2 [cytosol]
(R-HSA-1013845)
0.643
3
UniProt:Q12767 TMM94
0.643
3
UniProt:O43427 FIBP
0.643
3
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
2
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [cytosol]
(R-HSA-390464)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
0.527
2
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
2
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.527
2
UniProt:P50990 CCT8
5
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
0.527
2
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.527
2
UniProt:P20248 CCNA2
3
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.527
2
UniProt:P37231-2 PPARG
0.508
2
UniProt:Q5MJ70 SPDYA
0.488
2
UniProt:Q6FHY5 Q6FHY5
0.488
2
UniProt:A6NLX3 SPDE4
0.488
2
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